Human tactile FA1 neurons (Hay and Pruszynski 2020)

 Download zip file 
Help downloading and running models
Accession:266798
"... we show that synaptic integration across the complex signals from the first-order neuronal population could underlie human ability to accurately (< 3°) and rapidly process the orientation of edges moving across the fingertip. We first derive spiking models of human first-order tactile neurons that fit and predict responses to moving edges with high accuracy. We then use the model neurons in simulating the peripheral neuronal population that innervates a fingertip. We train classifiers performing synaptic integration across the neuronal population activity, and show that synaptic integration across first-order neurons can process edge orientations with high acuity and speed. ... our models suggest that integration of fast-decaying (AMPA-like) synaptic inputs within short timescales is critical for discriminating fine orientations, whereas integration of slow-decaying (NMDA-like) synaptic inputs supports discrimination of coarser orientations and maintains robustness over longer timescales"
Reference:
1 . Hay E, Pruszynski JA (2020) Orientation processing by synaptic integration across first-order tactile neurons. PLoS Comput Biol 16:e1008303 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon; Realistic Network;
Brain Region(s)/Organism: Human;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Sensory coding; Synaptic Integration; Receptive field;
Implementer(s):
Search NeuronDB for information about:  AMPA; NMDA;
/
Hay2020
models
c1_models_1_10.mat
c1_models_1_20.mat
c1_models_1_30.mat
c1_models_1_40.mat
c10_models_1_10.mat
c10_models_1_20.mat
c10_models_1_30.mat
c10_models_1_40.mat
c11_models_1_10.mat
c11_models_1_20.mat
c11_models_1_30.mat
c11_models_1_40.mat
c12_models_1_10.mat
c12_models_1_20.mat
c12_models_1_30.mat
c12_models_1_40.mat
c13_models_1_10.mat
c13_models_1_20.mat
c13_models_1_30.mat
c13_models_1_40.mat
c15_models_1_10.mat
c15_models_1_20.mat
c15_models_1_30.mat
c15_models_1_40.mat
c16_models_1_10.mat
c16_models_1_20.mat
c16_models_1_30.mat
c16_models_1_40.mat
c17_models_1_10.mat
c17_models_1_20.mat
c17_models_1_30.mat
c17_models_1_40.mat
c18_models_1_10.mat
c18_models_1_20.mat
c18_models_1_30.mat
c18_models_1_40.mat
c2_models_1_10.mat
c2_models_1_20.mat
c2_models_1_30.mat
c2_models_1_40.mat
c3_models_1_10.mat
c3_models_1_20.mat
c3_models_1_30.mat
c3_models_1_40.mat
c4_models_1_10.mat
c4_models_1_20.mat
c4_models_1_30.mat
c4_models_1_40.mat
c5_models_1_10.mat
c5_models_1_20.mat
c5_models_1_30.mat
c5_models_1_40.mat
c6_models_1_10.mat
c6_models_1_20.mat
c6_models_1_30.mat
c6_models_1_40.mat
c7_models_1_10.mat
c7_models_1_20.mat
c7_models_1_30.mat
c7_models_1_40.mat
c8_models_1_10.mat
c8_models_1_20.mat
c8_models_1_30.mat
c8_models_1_40.mat
c9_models_1_10.mat
c9_models_1_20.mat
c9_models_1_30.mat
c9_models_1_40.mat
N1acc1_1_nc1_nz0_tw0_ga.mat *
N1acc1_1_nc1_nz0_tw10_ga.mat *
N1acc1_1_nc1_nz0_tw20_ga.mat *
N1acc1_1_nc1_nz0_tw5_ga.mat *
N1acc1_1_nc1_nz0_tw50_ga.mat *
N1acc1_1_nc1_nz1_tw0_ga.mat
N1acc1_1_nc1_nz1_tw10_ga.mat
N1acc1_1_nc1_nz1_tw20_ga.mat
N1acc1_1_nc1_nz1_tw5_ga.mat
N1acc1_1_nc1_nz1_tw50_ga.mat
N1acc1_1_nc1_nz10_tw0_ga.mat
N1acc1_1_nc1_nz10_tw10_ga.mat
N1acc1_1_nc1_nz10_tw20_ga.mat
N1acc1_1_nc1_nz10_tw5_ga.mat
N1acc1_1_nc1_nz10_tw50_ga.mat
N1acc1_1_nc1_nz5_tw0_ga.mat
N1acc1_1_nc1_nz5_tw10_ga.mat
N1acc1_1_nc1_nz5_tw20_ga.mat
N1acc1_1_nc1_nz5_tw5_ga.mat
N1acc1_1_nc1_nz5_tw50_ga.mat
N1acc1_1_nc2_nz0_tw0_ga.mat *
N1acc1_1_nc2_nz0_tw10_ga.mat *
N1acc1_1_nc2_nz0_tw20_ga.mat *
N1acc1_1_nc2_nz0_tw5_ga.mat *
N1acc1_1_nc2_nz0_tw50_ga.mat *
N1acc1_1_nc2_nz1_tw0_ga.mat
N1acc1_1_nc2_nz1_tw10_ga.mat
N1acc1_1_nc2_nz1_tw20_ga.mat
N1acc1_1_nc2_nz1_tw5_ga.mat
N1acc1_1_nc2_nz1_tw50_ga.mat
N1acc1_1_nc2_nz10_tw0_ga.mat
N1acc1_1_nc2_nz10_tw10_ga.mat
N1acc1_1_nc2_nz10_tw20_ga.mat
N1acc1_1_nc2_nz10_tw5_ga.mat
N1acc1_1_nc2_nz10_tw50_ga.mat
N1acc1_1_nc2_nz5_tw0_ga.mat
N1acc1_1_nc2_nz5_tw10_ga.mat
N1acc1_1_nc2_nz5_tw20_ga.mat
N1acc1_1_nc2_nz5_tw5_ga.mat
N1acc1_1_nc2_nz5_tw50_ga.mat
N1angles1_0.mat
N1angles1_1.mat
N1angles1_10.mat
N1angles1_5.mat
N1wnc1_1_nc1_nz10_tw5_ang1_ga.mat
N1wnc1_1_nc1_nz10_tw5_ang10_ga.mat
N1wnc1_1_nc1_nz10_tw5_ang15_ga.mat
N1wnc1_1_nc1_nz10_tw5_ang20_ga.mat
N1wnc1_1_nc1_nz10_tw5_ang3_ga.mat
N1wnc1_1_nc1_nz10_tw5_ang5_ga.mat
N1wnc1_1_nc1_nz10_tw50_ang1_ga.mat
N1wnc1_1_nc1_nz10_tw50_ang10_ga.mat
N1wnc1_1_nc1_nz10_tw50_ang15_ga.mat
N1wnc1_1_nc1_nz10_tw50_ang20_ga.mat
N1wnc1_1_nc1_nz10_tw50_ang3_ga.mat
N1wnc1_1_nc1_nz10_tw50_ang5_ga.mat
N1wnc1_1_nc1_nz5_tw5_ang1_ga.mat
N1wnc1_1_nc1_nz5_tw5_ang10_ga.mat
N1wnc1_1_nc1_nz5_tw5_ang15_ga.mat
N1wnc1_1_nc1_nz5_tw5_ang20_ga.mat
N1wnc1_1_nc1_nz5_tw5_ang3_ga.mat
N1wnc1_1_nc1_nz5_tw5_ang5_ga.mat
N1wnc1_1_nc1_nz5_tw50_ang1_ga.mat
N1wnc1_1_nc1_nz5_tw50_ang10_ga.mat
N1wnc1_1_nc1_nz5_tw50_ang15_ga.mat
N1wnc1_1_nc1_nz5_tw50_ang20_ga.mat
N1wnc1_1_nc1_nz5_tw50_ang3_ga.mat
N1wnc1_1_nc1_nz5_tw50_ang5_ga.mat
N1wnc1_1_nc2_nz10_tw5_ang1_ga.mat
N1wnc1_1_nc2_nz10_tw5_ang10_ga.mat
N1wnc1_1_nc2_nz10_tw5_ang15_ga.mat
N1wnc1_1_nc2_nz10_tw5_ang20_ga.mat
N1wnc1_1_nc2_nz10_tw5_ang3_ga.mat
N1wnc1_1_nc2_nz10_tw5_ang5_ga.mat
N1wnc1_1_nc2_nz10_tw50_ang1_ga.mat
N1wnc1_1_nc2_nz10_tw50_ang10_ga.mat
N1wnc1_1_nc2_nz10_tw50_ang15_ga.mat
N1wnc1_1_nc2_nz10_tw50_ang20_ga.mat
N1wnc1_1_nc2_nz10_tw50_ang3_ga.mat
N1wnc1_1_nc2_nz10_tw50_ang5_ga.mat
N1wnc1_1_nc2_nz5_tw5_ang1_ga.mat
N1wnc1_1_nc2_nz5_tw5_ang10_ga.mat
N1wnc1_1_nc2_nz5_tw5_ang15_ga.mat
N1wnc1_1_nc2_nz5_tw5_ang20_ga.mat
N1wnc1_1_nc2_nz5_tw5_ang3_ga.mat
N1wnc1_1_nc2_nz5_tw5_ang5_ga.mat
N1wnc1_1_nc2_nz5_tw50_ang1_ga.mat
N1wnc1_1_nc2_nz5_tw50_ang10_ga.mat
N1wnc1_1_nc2_nz5_tw50_ang15_ga.mat
N1wnc1_1_nc2_nz5_tw50_ang20_ga.mat
N1wnc1_1_nc2_nz5_tw50_ang3_ga.mat
N1wnc1_1_nc2_nz5_tw50_ang5_ga.mat
N4acc1_1_nc1_nz10_tw0_ga.mat
N4acc1_1_nc1_nz10_tw5_ga.mat
N4acc1_1_nc1_nz5_tw0_ga.mat
N4acc1_1_nc1_nz5_tw5_ga.mat
N4acc1_1_nc2_nz10_tw0_ga.mat
N4acc1_1_nc2_nz5_tw0_ga.mat
N4acc1_1_nc2_nz5_tw5_ga.mat
N4angles1_10.mat
N4angles1_5.mat
selected_models_1.mat
                            
ModelDB scripts have detected that binary file '/Hay2020/models/N4acc1_1_nc1_nz5_tw0_ga.mat' is not displayable. You may download the file to examine if desired.

<- Select file from this column.