Purkinje neuron network (Zang et al. 2020)

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Accession:266799
Both spike rate and timing can transmit information in the brain. Phase response curves (PRCs) quantify how a neuron transforms input to output by spike timing. PRCs exhibit strong firing-rate adaptation, but its mechanism and relevance for network output are poorly understood. Using our Purkinje cell (PC) model we demonstrate that the rate adaptation is caused by rate-dependent subthreshold membrane potentials efficiently regulating the activation of Na+ channels. Then we use a realistic PC network model to examine how rate-dependent responses synchronize spikes in the scenario of reciprocal inhibition-caused high-frequency oscillations. The changes in PRC cause oscillations and spike correlations only at high firing rates. The causal role of the PRC is confirmed using a simpler coupled oscillator network model. This mechanism enables transient oscillations between fast-spiking neurons that thereby form PC assemblies. Our work demonstrates that rate adaptation of PRCs can spatio-temporally organize the PC input to cerebellar nuclei.
Reference:
1 . Zang Y, Hong S, De Schutter E (2020) Firing rate-dependent phase responses of Purkinje cells support transient oscillations. Elife [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Phase Response Curves; Action Potentials; Spatio-temporal Activity Patterns; Synchronization; Action Potential Initiation; Oscillations;
Implementer(s): Zang, Yunliang ; Hong, Sungho [shhong at oist.jp];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell;
function fh = copyfig(fh)
%COPYFIG Create a copy of a figure, without changing the figure
%
% Examples:
%   fh_new = copyfig(fh_old)
%
% This function will create a copy of a figure, but not change the figure,
% as copyobj sometimes does, e.g. by changing legends.
%
% IN:
%    fh_old - The handle of the figure to be copied. Default: gcf.
%
% OUT:
%    fh_new - The handle of the created figure.

% Copyright (C) Oliver Woodford 2012, Yair Altman 2015

% 26/02/15: If temp dir is not writable, use the dest folder for temp
%           destination files (Javier Paredes)
% 15/04/15: Suppress warnings during copyobj (Dun Kirk comment on FEX page 2013-10-02)
% 09/09/18: Fix issue #252: Workaround for cases where copyobj() fails for any reason

    % Set the default
    if nargin == 0
        fh = gcf;
    end
    % Is there a legend?
    useCopyobj = isempty(findall(fh, 'Type', 'axes', 'Tag', 'legend'));
    if useCopyobj
        % Safe to copy using copyobj
        oldWarn = warning('off'); %Suppress warnings during copyobj (Dun Kirk comment on FEX page 2013-10-02)
        try
            fh = copyobj(fh, 0);
        catch
            % Fix issue #252: Workaround for cases where copyobj() fails for any reason
            useCopyobj = false;  % if copyobj() croaks, use file save/load below
        end
        warning(oldWarn);
    end
    if ~useCopyobj
        % copyobj will change the figure, so save and then load it instead
        tmp_nam = [tempname '.fig'];
        try
            % Ensure that the temp dir is writable (Javier Paredes 26/2/15)
            fid = fopen(tmp_nam,'w');
            fwrite(fid,1);
            fclose(fid);
            delete(tmp_nam);  % cleanup
        catch
            % Temp dir is not writable, so use the current folder
            [dummy,fname,fext] = fileparts(tmp_nam); %#ok<ASGLU>
            fpath = pwd;
            tmp_nam = fullfile(fpath,[fname fext]);
        end
        hgsave(fh, tmp_nam);
        fh = hgload(tmp_nam);
        delete(tmp_nam);
    end
end