Purkinje neuron network (Zang et al. 2020)

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Accession:266799
Both spike rate and timing can transmit information in the brain. Phase response curves (PRCs) quantify how a neuron transforms input to output by spike timing. PRCs exhibit strong firing-rate adaptation, but its mechanism and relevance for network output are poorly understood. Using our Purkinje cell (PC) model we demonstrate that the rate adaptation is caused by rate-dependent subthreshold membrane potentials efficiently regulating the activation of Na+ channels. Then we use a realistic PC network model to examine how rate-dependent responses synchronize spikes in the scenario of reciprocal inhibition-caused high-frequency oscillations. The changes in PRC cause oscillations and spike correlations only at high firing rates. The causal role of the PRC is confirmed using a simpler coupled oscillator network model. This mechanism enables transient oscillations between fast-spiking neurons that thereby form PC assemblies. Our work demonstrates that rate adaptation of PRCs can spatio-temporally organize the PC input to cerebellar nuclei.
Reference:
1 . Zang Y, Hong S, De Schutter E (2020) Firing rate-dependent phase responses of Purkinje cells support transient oscillations. Elife [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Phase Response Curves; Action Potentials; Spatio-temporal Activity Patterns; Synchronization; Action Potential Initiation; Oscillations;
Implementer(s): Zang, Yunliang ; Hong, Sungho [shhong at oist.jp];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell;
%PDF2EPS  Convert a pdf file to eps format using pdftops
%
% Examples:
%   pdf2eps source dest
%
% This function converts a pdf file to eps format.
%
% This function requires that you have pdftops, from the Xpdf suite of
% functions, installed on your system. This can be downloaded from:
% http://xpdfreader.com
%
% Inputs:
%   source - filename of the source pdf file to convert. The filename is
%            assumed to already have the extension ".pdf".
%   dest - filename of the destination eps file. The filename is assumed to
%          already have the extension ".eps".

% Copyright (C) Oliver Woodford 2009-2010, Yair Altman 2015-

% Thanks to Aldebaro Klautau for reporting a bug when saving to
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% 22/09/2018 - Xpdf website changed to xpdfreader.com

function pdf2eps(source, dest)
    % Construct the options string for pdftops
    options = ['-q -paper match -eps -level2 "' source '" "' dest '"'];

    % Convert to eps using pdftops
    [status, message] = pdftops(options);

    % Check for error
    if status
        % Report error
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    % Fix the DSC error created by pdftops
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