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Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. 2021)
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We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons.
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Neuron or other electrically excitable cell;
Neocortex L5/6 pyramidal GLU cell;
Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
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Neocortex L5/6 pyramidal GLU cell
Neocortex M1 L5B pyramidal pyramidal tract GLU cell
Other models using ghk.inc:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
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