Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

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Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
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L5PYR_Resonance-master
models
AckerAntic
misc
gflucts
mod
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glutamate.mod *
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MyExp2SynBB.mod *
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NMDA.mod
NMDAeee.mod *
PlateauConductance.mod *
SK_E2.mod *
vecstim.mod *
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ghk.inc *
                            
COMMENT

Plateau-like conductance. Does not summate (1 shot only).

Corey Acker
September 2008

ENDCOMMENT

NEURON {
	POINT_PROCESS PlateauConductance
	RANGE onset, dur, tau_on, tau_off, gmax, e, i
	NONSPECIFIC_CURRENT i
    RANGE g
}
UNITS {
	(nA) = (nanoamp)
	(mV) = (millivolt)
	(uS) = (microsiemens)
}

PARAMETER {
	onset=0 (ms)
	dur=10 (ms)
	tau_on=.5 (ms)	<1e-3,1e6>
	tau_off=5 (ms)	<1e-3,1e6>
	gmax=0 (uS)	<0,1e9>
	e=0	(mV)
}

ASSIGNED { i (nA) g (uS) }

INITIAL {
	i = 0
      g = 0
}

BREAKPOINT {
	if (gmax) {
         at_time(onset)
         at_time(onset+dur)
      }
      if (t-onset < 0 || t-onset > 5*tau_off+dur) {
            i = 0
      } else {
            if (t - onset < dur) {
                 g = gmax*(1-exp(-(t-onset)/tau_on))
            } else {
                 g = gmax*(1-exp(-dur/tau_on))*exp(-(t-dur-onset)/tau_off)
            }
            i = g*(v-e)
      }
}