Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
/
L5PYR_Resonance-master
models
DuraBernal
mod
ar_traub.mod *
cadad.mod *
cadyn.mod *
cagk.mod *
cal_mh.mod *
cal_mig.mod *
can_mig.mod *
canin.mod *
cat_mig.mod *
cat_traub.mod *
catcb.mod *
gabab.mod *
h_BS.mod *
h_harnett.mod
h_kole.mod *
h_migliore.mod *
HCN1.mod *
hin.mod *
IC.mod *
ican_sidi.mod *
IKsin.mod *
kap_BS.mod *
kapcb.mod *
kapin.mod *
kBK.mod *
kctin.mod *
kdmc_BS.mod *
kdr_BS.mod *
kdrin.mod *
MyExp2SynBB.mod *
MyExp2SynNMDABB.mod *
nafx.mod *
nap_sidi.mod *
nax_BS.mod *
savedist.mod *
vecstim.mod *
ghk.inc *
misc.h
parameters.multi *
                            
:DEFAULT clampex
:DEFAULT misc
:DEFAULT stats
:DEFAULT infot

:DEFAULT vecst
:DEFAULT nstim
:DEFAULT samnutils

DEFAULT MyExp2SynBB
DEFAULT MyExp2SynNMDABB
:DEFAULT izhi2007a
:DEFAULT izhi2007b
 
: Ben Suter ion channels
DEFAULT h_BS
DEFAULT kap_BS
DEFAULT kdmc_BS
DEFAULT kdr_BS
DEFAULT nax_BS

: Mainen/Sej cell ion channels
:DEFAULT naz
:DEFAULT km
:DEFAULT kv
:DEFAULT kca
:DEFAULT Nca
DEFAULT cadad

: mig ion channels
DEFAULT cat_mig
DEFAULT can_mig
DEFAULT cal_mig

: calcium activated k channel
DEFAULT cagk

: k channel with ca and voltage dependence - responsible for fast part of AHP
DEFAULT IC

: from Ben
DEFAULT savedist

: Harnett 2015 H channel
DEFAULT h_harnett

: Kole 2006 H channel
DEFAULT h_kole

: Migliore 2012 H channel
DEFAULT h_migliore

: BK channel with ca and voltage dependence
DEFAULT kBK

: ih used for basket cells
DEFAULT HCN1

: channels for LTS1
:DEFAULT na2_mh
: ar is HCN - anomalous rectifier
DEFAULT ar_traub
DEFAULT cat_traub
DEFAULT cal_mh

: persistent sodium channel
DEFAULT nap_sidi
: ican (calcium dependent cation non-specific channel)
DEFAULT ican_sidi

: based on destexhe
DEFAULT gabab

: homeostatic synapse
:DEFAULT hsyn

: Channels for 3-comp FScell 
DEFAULT nafx
DEFAULT kdrin
DEFAULT IKsin
DEFAULT hin
DEFAULT canin
DEFAULT kapin
DEFAULT kctin
DEFAULT cadyn

: Channels for 3-comp LTScell 
DEFAULT kapcb
DEFAULT catcb

:Vecstim used for long-range pops
DEFAULT vecstim