Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

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Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
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L5PYR_Resonance-master
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ghk.inc *
                            
: from
:  http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=144490&file=\bpap\ghk.inc

COMMENT
    GHK function that returns effective driving force
    Slope at low voltages is 1
    z needs to be set as a PARAMETER
ENDCOMMENT

FUNCTION ghkg(v(mV), ci(mM), co(mM), z) (mV) {
    LOCAL xi, f, exi, fxi
    f = R*(celsius+273.15)/(z*(1e-3)*FARADAY)
    xi = v/f
    exi = exp(xi)
    if (fabs(xi) < 1e-4) {
        fxi = 1 - xi/2
    }else{
        fxi = xi/(exi - 1)
    }
    ghkg = f*((ci/co)*exi - 1)*fxi
}

FUNCTION ghk(v(mV), ci(mM), co(mM), z) (.001 coul/cm3) {
    LOCAL xi, f, exi, fxi
    f = R*(celsius+273.15)/(z*(1e-3)*FARADAY)
    xi = v/f
    exi = exp(xi)
    if (fabs(xi) < 1e-4) {
        fxi = 1 - xi/2
    }else{
        fxi = xi/(exi - 1)
    }
    ghk = (.001)*z*FARADAY*(ci*exi - co)*fxi
}