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Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al 2021)
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Accession:
267067
Based on the Layer 5 thick-tufted pyramidal cell from the Blue Brain Project, we modify the distribution of the sodium channel Nav1.2 to recapitulate an increase in excitability observed in ex vivo slice experiments.
Reference:
1 .
Spratt PWE, Alexander RPD, Ben-Shalom R, Sahagun A, Kyoung H, Keeshen CM, Sanders SJ, Bender KJ (2021) Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells
Cell Rep.
36(5)
:109483
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Prefrontal cortex (PFC);
Cell Type(s):
Neocortex layer 5 pyramidal cell;
Channel(s):
I h;
I M;
I Potassium;
I Sodium;
I L high threshold;
I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Nav1.2 SCN2A;
Transmitter(s):
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Implementer(s):
Ben-Shalom, Roy [rbenshalom at ucdavis.edu];
Kyoung, Henry [hkyoung at berkeley.edu];
Search NeuronDB
for information about:
I L high threshold
;
I T low threshold
;
I M
;
I h
;
I Sodium
;
I Potassium
;
/
SprattEtAl2021
Ri Increase
.ipynb_checkpoints
mechanisms
morphology
params
Stims
Volts
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Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
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