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Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
 
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Model Information
Model File
Accession:
34558
It has been found that in cultured Aplysia neurons bath applications of 40 mM cafffeine evokes oscillations of the membrane potential with about a 40 mV amplitude with a frequency of 0.2 to 0.5 Hz. The most probable mechanism of these caffeine-induced oscillations is inhibition of voltage-activated outward potassium current and, as can be seen from our mathematical modeling, slowdown of inactivation of inward sodium current. It seems likely that these oscillations have a purely membrane origin. Please see paper for results and details.
Reference:
1 .
Komendantov AO, Kononenko NI (2000) Caffeine-induced oscillations of the membrane potential in Aplysia Neurons.
Neirofiziologiya/Neurophysiology
32
:102-111
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Aplysia cultured neuron;
Channel(s):
I Na,t;
I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
SNNAP;
Model Concept(s):
Activity Patterns;
Bursting;
Oscillations;
Action Potentials;
Invertebrate;
Implementer(s):
Komendantov, Alexander O [akomenda at tulane.edu];
Kononenko, Nikolai I [nik137 at lamar.colostate.edu];
Search NeuronDB
for information about:
I Na,t
;
I K
;
/
Komendantov
control
Fig_6
Fig_7
xls
README.txt
L7.neu
*
Other models using L7.neu:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7.ntw
*
Other models using L7.ntw:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7_01.ous
*
Other models using L7_01.ous:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7_01.smu
*
Other models using L7_01.smu:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7_01.trt
*
Other models using L7_01.trt:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7_01_smu.jpg
L7_K.a
*
Other models using L7_K.a:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7_K.vdg
*
Other models using L7_K.vdg:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7_leak.vdg
*
Other models using L7_leak.vdg:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7_Na.A
*
Other models using L7_Na.A:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7_Na.B
*
Other models using L7_Na.B:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
L7_Na.vdg
*
Other models using L7_Na.vdg:
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
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