MicrocircuitDB: Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)

Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)

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Accession:34558

It has been found that in cultured Aplysia neurons bath applications of 40 mM cafffeine evokes oscillations of the membrane potential with about a 40 mV amplitude with a frequency of 0.2 to 0.5 Hz. The most probable mechanism of these caffeine-induced oscillations is inhibition of voltage-activated outward potassium current and, as can be seen from our mathematical modeling, slowdown of inactivation of inward sodium current. It seems likely that these oscillations have a purely membrane origin. Please see paper for results and details.
Reference:
1 . Komendantov AO, Kononenko NI (2000) Caffeine-induced oscillations of the membrane potential in Aplysia Neurons. Neirofiziologiya/Neurophysiology 32:102-111

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Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Aplysia cultured neuron;
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	SNNAP;
Model Concept(s):	Activity Patterns; Bursting; Oscillations; Action Potentials; Invertebrate;
Implementer(s):	Komendantov, Alexander O [akomenda at tulane.edu]; Kononenko, Nikolai I [nik137 at lamar.colostate.edu];