Dentate Basket Cell: spatial summation of inhibitory synaptic inputs (Bartos et al 2001)

 Download zip file   Auto-launch 
Help downloading and running models
Spatial summation of inhibitory synaptic input in a passive model of a basket cell from the dentate gyrus of rat hippocampus. Reproduces Figs. 5Ac and d in Bartos, M., Vida, I., Frotscher, M., Geiger, J.R.P, and Jonas, P.. Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience 21:2687-2698, 2001.
1 . Bartos M, Vida I, Frotscher M, Geiger JR, Jonas P (2001) Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. J Neurosci 21:2687-98 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus basket cell;
Gap Junctions:
Receptor(s): GabaA;
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Influence of Dendritic Geometry; Detailed Neuronal Models;
Implementer(s): Carnevale, Ted [Ted.Carnevale at];
Search NeuronDB for information about:  GabaA; Gaba;

v_init = -70	// mV
tstop = 25	// mS

objref ginitial
ginitial = new Vector(3)
for ii = 0,2 {
  // make sure this isn't undone by session saves
//  syn2[ii].gmax = 0.00354
  syn2[ii].gmax = 0.0158/3
  syn2[ii].tau0 = 0.2
  syn2[ii].tau1 = 1.02
  ginitial.x[ii] = syn2[ii].gmax

proc doit() {
  if ($1==3) {
    // restore initial gmax to all
    for ii = 0,2 {
      syn2[ii].gmax = ginitial.x[ii]
  } else {
    for ii = 0,2 {
      syn2[ii].gmax = 0
    syn2[$1].gmax = ginitial.x[$1]

xpanel("kludge", 0)
xbutton("All three synaptic terminals are active","doit(3)")
xlabel("Fig.5Bd: 'quantal' components")
xbutton("synapse 0 only","doit(0)")
xbutton("synapse 1 only","doit(1)")
xbutton("synapse 2 only","doit(2)")

xpanel("message", 0)
xlabel("The CellBuilder specifies the detailed quantitative morphology")
xlabel("of the model cell.  Extensive axonal branching is emulated by")
xlabel("a large number of 100 um diameter neurites that the authors")
xlabel("specified with hoc code (see axon_collat.hoc).  These are not")
xlabel("seen in the CellBuilder, but they appear as several brushlike")
xlabel("tufts in the shape plot associated with the")