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Olfactory bulb mitral cell: synchronization by gap junctions (Migliore et al 2005)
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Accession:
43039
In a realistic model of two electrically connected mitral cells, the paper shows that the somatically-measured experimental properties of Gap Junctions (GJs) may correspond to a variety of different local coupling strengths and dendritic distributions of GJs in the tuft. The model suggests that the propagation of the GJ-induced local tuft depolarization is a major mechanim for intraglomerular synchronization of mitral cells.
Reference:
1 .
Migliore M, Hines ML, Shepherd GM (2005) The role of distal dendritic gap junctions in synchronization of mitral cell axonal output.
J Comput Neurosci
18
:151-61
[
PubMed
]
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Model Information
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Model Type:
Realistic Network;
Brain Region(s)/Organism:
Olfactory bulb;
Cell Type(s):
Olfactory bulb main mitral GLU cell;
Channel(s):
I Na,t;
I A;
I K;
Gap Junctions:
Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Dendritic Action Potentials;
Synchronization;
Active Dendrites;
Influence of Dendritic Geometry;
Olfaction;
Implementer(s):
Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB
for information about:
Olfactory bulb main mitral GLU cell
;
I Na,t
;
I A
;
I K
;
Download the displayed file
/
gap-modeldb
readme.txt
kamt.mod
*
Other models using kamt.mod:
CA1 oriens alveus interneurons: signaling properties (Minneci et al. 2007)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Olfactory Computations in Mitral-Granule cell circuits (Migliore & McTavish 2013)
Olfactory bulb granule cell: effects of odor deprivation (Saghatelyan et al 2005)
Olfactory bulb mitral and granule cell column formation (Migliore et al. 2007)
Olfactory bulb mitral and granule cell: dendrodendritic microcircuits (Migliore and Shepherd 2008)
kdrmt.mod
*
Other models using kdrmt.mod:
Olfactory Computations in Mitral-Granule cell circuits (Migliore & McTavish 2013)
Olfactory bulb granule cell: effects of odor deprivation (Saghatelyan et al 2005)
Olfactory bulb mitral and granule cell column formation (Migliore et al. 2007)
Olfactory bulb mitral and granule cell: dendrodendritic microcircuits (Migliore and Shepherd 2008)
naxn.mod
*
Other models using naxn.mod:
CA1 oriens alveus interneurons: signaling properties (Minneci et al. 2007)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Olfactory Computations in Mitral-Granule cell circuits (Migliore & McTavish 2013)
Olfactory bulb granule cell: effects of odor deprivation (Saghatelyan et al 2005)
Olfactory bulb mitral and granule cell column formation (Migliore et al. 2007)
Olfactory bulb mitral and granule cell: dendrodendritic microcircuits (Migliore and Shepherd 2008)
correl.hoc
forfig6-modeldb.hoc
gap.hoc
*
Other models using gap.hoc:
A network model of the vertebrate retina (Publio et al. 2009)
CA1 oriens alveus interneurons: signaling properties (Minneci et al. 2007)
mitral-modeldb.hoc
mosinit.hoc
load_file("forfig6-modeldb.hoc")
Load Model Views
control - no GJ (fig.6A)
with GJ & Na+ block (fig.6C)
with GJ (fig.6B)
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