Ribbon Synapse (Sikora et al 2005)

 Download zip file   Auto-launch 
Help downloading and running models
A model of the ribbon synapse was developed to replicate both pre- and postsynaptic functions of this glutamatergic juncture. The presynaptic portion of the model is rich in anatomical and physiological detail and includes multiple release sites for each ribbon based on anatomical studies of presynaptic terminals, presynaptic voltage at the terminal, the activation of voltage-gated calcium channels and a calcium-dependent release mechanism whose rate varies as a function of the calcium concentration that is monitored at two different sites which control both an ultrafast, docked pool of vesicles and a release ready pool of tethered vesicles. See paper for more and details.
1 . Sikora MA, Gottesman J, Miller RF (2005) A computational model of the ribbon synapse. J Neurosci Methods 145:47-61 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Retina ganglion GLU cell; Retina bipolar GLU cell;
Channel(s): I L high threshold;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Intrinsic plasticity; Calcium dynamics;
Implementer(s): Sikora, Michael [Sikora at umn.edu];
Search NeuronDB for information about:  Retina ganglion GLU cell; Retina bipolar GLU cell; AMPA; NMDA; I L high threshold; Glutamate;

strdef tstr

xpanel("Figures for Sikora et al, 2005")
xlabel("Press a button to create the figure")
xradiobutton("7", "restart(\"makefig7\")")
xradiobutton("8a", "restart(\"makefig8a\")")
xradiobutton("8b", "restart(\"makefig8b\")")
xradiobutton("8c", "restart(\"makefig8c\")")
xradiobutton("8c_250", "restart(\"makefig8c_250ms\")")
xradiobutton("9-11", "restart(\"fig9-11\")")
xlabel("Figures 9-11 demo requires \"Init & \Run\" to be pressed")
xlabel("so that parameters can be changed beforehand if desired.")

pwmcnt = PWManager[0].count // the initial gui should not be dismissed

proc restart() {local i
	objref graphItem, save_window_
	for i=0, n_graph_lists-1 {
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
	sprint(tstr, "%s.hoc", $s1)
	load_file(1, tstr)