T channel currents (Vitko et al 2005)

 Download zip file   Auto-launch 
Help downloading and running models
Computer simulations predict that seven of the SNPs would increase firing of neurons, with three of them inducing oscillations at similar frequencises. 3 representative models from the paper have been submited: a wild-type (WT) recombinant Cav3.2 T-channel, and two of the mutants described in the Vitko et al., 2005 paper (C456S and R788C). See the paper for more and details.
1 . Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E (2005) Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J Neurosci 25:4844-55 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I T low threshold;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Epilepsy;
Search NeuronDB for information about:  I T low threshold;
  Geometry file for thalamic reticular neuron

  - 1 compartment (soma)

  Length and diameters:

	Soma :		L=64.86	um	diam=70 um2	S=14263 um2

	   Reconstructed RE cell was of 13302.9 um2

  For more details, see:

  Destexhe, A., Contreras, D., Steriade, M., Sejnowski, T.J. and Huguenard,
  J.R.  In vivo, in vitro and computational analysis of dendritic calcium
  currents in thalamic reticular neurons.  J. Neurosci. 16: 169-185, 1996.

  See also:



print "----------------------------------------------"
print "Simplified reticular cell with 1 compartment"
print "----------------------------------------------"

/* create compartments (sections) */

create soma[1]

soma {
  nseg = 1
  diam = 70
  L = 64.86