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Simulated light response in rod photoreceptors (Liu and Kourennyi 2004)
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Accession:
64228
We developed a complete computer model of the rod, which accurately reproduced the main features of the light response and allowed us to demonstrate that it was suppression of Kx channels that was essential for slowing SLR and increasing excitability of rods. The results reported in this work further establish the importance of Kx channels in rod photoreceptor function.
Reference:
1 .
Liu XD, Kourennyi DE (2004) Effects of tetraethylammonium on Kx channels and simulated light response in rod photoreceptors.
Ann Biomed Eng
32
:1428-42
[
PubMed
]
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Retina photoreceptor cone GLU cell;
Channel(s):
I Chloride;
I L high threshold;
I K;
I h;
I K,Ca;
I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Oscillations;
Action Potentials;
Calcium dynamics;
Implementer(s):
Kourennyi, Dmitri E [dek at case.edu];
Liu, Xiaodong [xliu22 at jhmi.edu];
Search NeuronDB
for information about:
Retina photoreceptor cone GLU cell
;
I Chloride
;
I L high threshold
;
I K
;
I h
;
I K,Ca
;
I Potassium
;
Download the displayed file
/
Liu-Kourennyi_2004
readme.txt
Ca.mod
*
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rod.hoc
load_file("nrngui.hoc") load_file("init.hoc")
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Fig5_IVCompare
Fig9_AP_Patterns
Kx_BR
Kx_DIM
fig 8B. AP_BR
fig 8D. AP_DIM
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