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CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)
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Model Information
Model File
Accession:
71312
The model shows how different input patterns (irregular & asynchronous, irregular & synchronous, regular & asynchronous, regular & synchronous) affect the neuron's output rate when 1000 synapses are distributed in the proximal apical dendritic tree of a hippocampus CA1 pyramidal neuron.
Reference:
1 .
Li X, Ascoli GA (2006) Computational simulation of the input-output relationship in hippocampal pyramidal cells.
J Comput Neurosci
21
:191-209
[
PubMed
]
2 .
Li X, Ascoli GA (2008) Effects of synaptic synchrony on the neuronal input-output relationship.
Neural Comput
20
:1717-31
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Na,t;
I A;
I K;
I h;
Gap Junctions:
Receptor(s):
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Detailed Neuronal Models;
Synaptic Integration;
Implementer(s):
Li, Xiaoshen [xsli2 at yahoo.com];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
AMPA
;
NMDA
;
I Na,t
;
I A
;
I K
;
I h
;
Download the displayed file
/
xiaoshenli
readme.txt
distr.mod
*
Other models using distr.mod:
CA1 pyramidal neuron: Ih current (Migliore et al. 2012)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Ca3 pyramidal neuron: membrane response near rest (Hemond et al. 2009)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Model of CA1 activity during working memory task (Spera et al. 2016)
Modulation of temporal integration window (Migliore, Shepherd 2002)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
h.mod
*
Other models using h.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Conductance based model for short term plasticity at CA3-CA1 synapses (Mukunda & Narayanan 2017)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Model of CA1 activity during working memory task (Spera et al. 2016)
Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
kadist.mod
*
Other models using kadist.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
A model of unitary responses from A/C and PP synapses in CA3 pyramidal cells (Baker et al. 2010)
CA1 pyramidal neuron (Migliore et al 1999)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Calcium waves and mGluR-dependent synaptic plasticity in CA1 pyr. neurons (Ashhad & Narayanan 2013)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Model of CA1 activity during working memory task (Spera et al. 2016)
Modulation of hippocampal rhythms by electric fields and network topology (Berzhanskaya et al. 2013)
Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
Sympathetic Preganglionic Neurone (Briant et al. 2014)
kaprox.mod
*
Other models using kaprox.mod:
CA1 pyramidal neuron (Migliore et al 1999)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neuron: integration of subthreshold inputs from PP and SC (Migliore 2003)
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Calcium waves and mGluR-dependent synaptic plasticity in CA1 pyr. neurons (Ashhad & Narayanan 2013)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Estimation and Production of Time Intervals (Migliore et al 2001)
Excitability of PFC Basal Dendrites (Acker and Antic 2009)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)
Model of CA1 activity during working memory task (Spera et al. 2016)
Modulation of hippocampal rhythms by electric fields and network topology (Berzhanskaya et al. 2013)
Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Small world networks of Type I and Type II Excitable Neurons (Bogaard et al. 2009)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
Sympathetic Preganglionic Neurone (Briant et al. 2014)
kdrca1.mod
*
Other models using kdrca1.mod:
CA1 pyramidal neuron (Migliore et al 1999)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neuron: integration of subthreshold inputs from PP and SC (Migliore 2003)
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Estimation and Production of Time Intervals (Migliore et al 2001)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)
Model of CA1 activity during working memory task (Spera et al. 2016)
Modulation of hippocampal rhythms by electric fields and network topology (Berzhanskaya et al. 2013)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Small world networks of Type I and Type II Excitable Neurons (Bogaard et al. 2009)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
Vomeronasal sensory neuron (Shimazaki et al 2006)
na3n.mod
*
Other models using na3n.mod:
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Model of CA1 activity during working memory task (Spera et al. 2016)
naxn.mod
*
Other models using naxn.mod:
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Model of CA1 activity during working memory task (Spera et al. 2016)
Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006)
c20466.hoc
createNewSyn.hoc
createNewSyn2.hoc
exec.hoc
fig4A.hoc
fixnseg.hoc
*
Other models using fixnseg.hoc:
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
ModelTypeC.hoc
ModelTypeI.hoc
mosinit.hoc
NregNsyn.hoc
Nregsyn.hoc
regNsyn.hoc
*
Other models using regNsyn.hoc:
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
load_file("nrngui.hoc") xopen("fig4A.hoc")
