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A single column thalamocortical network model (Traub et al 2005)
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Model Information
Model File
Accession:
45539
To better understand population phenomena in thalamocortical neuronal ensembles, we have constructed a preliminary network model with 3,560 multicompartment neurons (containing soma, branching dendrites, and a portion of axon). Types of neurons included superficial pyramids (with regular spiking [RS] and fast rhythmic bursting [FRB] firing behaviors); RS spiny stellates; fast spiking (FS) interneurons, with basket-type and axoaxonic types of connectivity, and located in superficial and deep cortical layers; low threshold spiking (LTS) interneurons, that contacted principal cell dendrites; deep pyramids, that could have RS or intrinsic bursting (IB) firing behaviors, and endowed either with non-tufted apical dendrites or with long tufted apical dendrites; thalamocortical relay (TCR) cells; and nucleus reticularis (nRT) cells. To the extent possible, both electrophysiology and synaptic connectivity were based on published data, although many arbitrary choices were necessary.
Reference:
1 .
Traub RD, Contreras D, Cunningham MO, Murray H, LeBeau FE, Roopun A, Bibbig A, Wilent WB, Higley MJ, Whittington MA (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts.
J Neurophysiol
93
:2194-232
[
PubMed
]
2 .
Traub RD, Contreras D, Whittington MA (2005) Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.
J Clin Neurophysiol
22
:330-42
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Thalamus;
Cell Type(s):
Thalamus geniculate nucleus/lateral principal GLU cell;
Thalamus reticular nucleus GABA cell;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
I A, slow;
Gap Junctions:
Gap junctions;
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
FORTRAN;
Model Concept(s):
Activity Patterns;
Bursting;
Temporal Pattern Generation;
Oscillations;
Simplified Models;
Epilepsy;
Sleep;
Spindles;
Implementer(s):
Traub, Roger D [rtraub at us.ibm.com];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
Thalamus reticular nucleus GABA cell
;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell
;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell
;
GabaA
;
AMPA
;
NMDA
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
I A, slow
;
Files displayed below are from the
ifc fortran
g77
NEURON
neuroConstruct
implementation
Download the displayed file
/
nrntraub
cells
dat
hoc
mod
net
README
balanal.hoc
*
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Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
balcomp.hoc
*
Other models using balcomp.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
cell_templates.hoc
*
Other models using cell_templates.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
clear.hoc
*
Other models using clear.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
finit.hoc
*
Other models using finit.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
fortmap.hoc
*
Other models using fortmap.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
gidcell.hoc
*
Other models using gidcell.hoc:
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
gidcell.ses
*
Other models using gidcell.ses:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
init.hoc
manage_setup.hoc
mosinit.hoc
*
Other models using mosinit.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
onecell.hoc
*
Other models using onecell.hoc:
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
onecell.ses
*
Other models using onecell.ses:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
prcellstate.hoc
*
Other models using prcellstate.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
printcon.hoc
*
Other models using printcon.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
savestatetest.sh
spkplt.hoc
*
Other models using spkplt.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
vclampg.hoc
*
Other models using vclampg.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
vcompclamp.hoc
*
Other models using vcompclamp.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
vcompsim.hoc
*
Other models using vcompsim.hoc:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
//moddir mod {load_file("nrngui.hoc")} {load_file("spkplt.hoc")} {load_file("onecell.hoc")}
