Advanced search
User account
Login
Register
Find models by
Model name
First author
Each author
Find models for
Brain region
Concept
Find models of
Realistic Microcircuits
Connectionist Networks
Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)
Download zip file
Auto-launch
Help downloading and running models
Model Information
Model File
Model Views
Simulation Platform
3D Print
c91662
Accession:
87284
The model simulations provide evidence oblique dendrites in CA1 pyramidal neurons are susceptible to hyper-excitability by amyloid beta block of the transient K+ channel, IA. See paper for details.
Reference:
1 .
Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM (2010) Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study.
Front Neural Circuits
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Na,t;
I L high threshold;
I N;
I T low threshold;
I A;
I K;
I h;
I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Dendritic Action Potentials;
Active Dendrites;
Detailed Neuronal Models;
Pathophysiology;
Aging/Alzheimer`s;
Implementer(s):
Carnevale, Ted [Ted.Carnevale at Yale.edu];
Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
I Na,t
;
I L high threshold
;
I N
;
I T low threshold
;
I A
;
I K
;
I h
;
I K,Ca
;
/
CA1_abeta
translate
readme.html
cacumm.mod
cagk.mod
*
Other models using cagk.mod:
A model of unitary responses from A/C and PP synapses in CA3 pyramidal cells (Baker et al. 2010)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA3 pyramidal neuron (Safiulina et al. 2010)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Neuronal dendrite calcium wave model (Neymotin et al, 2015)
cal2.mod
*
Other models using cal2.mod:
A model of unitary responses from A/C and PP synapses in CA3 pyramidal cells (Baker et al. 2010)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA3 pyramidal neuron (Safiulina et al. 2010)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Firing patterns of CA3 hippocampal neurons (Soldado-Magraner et al. 2019)
can2.mod
*
Other models using can2.mod:
A model of unitary responses from A/C and PP synapses in CA3 pyramidal cells (Baker et al. 2010)
CA3 pyramidal neuron (Safiulina et al. 2010)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Firing patterns of CA3 hippocampal neurons (Soldado-Magraner et al. 2019)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
cat.mod
*
Other models using cat.mod:
A model of unitary responses from A/C and PP synapses in CA3 pyramidal cells (Baker et al. 2010)
CA3 pyramidal neuron (Safiulina et al. 2010)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Firing patterns of CA3 hippocampal neurons (Soldado-Magraner et al. 2019)
distr.mod
*
Other models using distr.mod:
Compartmentalization of GABAergic inhibition by dendritic spines (Chiu et al. 2013)
h.mod
ipulse2.mod
*
Other models using ipulse2.mod:
Calcium and potassium currents of olfactory bulb juxtaglomerular cells (Masurkar and Chen 2011)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
kadist.mod
kaprox.mod
kdrca1.mod
na3n.mod
naxn.mod
*
Other models using naxn.mod:
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
zcaquant.mod
aBeta.hoc
add_ca.hoc
bAP_peak_vecs.hoc
c91662.ses
C91662_Link.txt
cond_report.hoc
control_boxes.hoc
distribute_currents.hoc
fig1.jpg
fig2.jpg
fig2A_c91662.hoc
fig3.jpg
fig3.ses
fig4.jpg
fig4.ses
fig5.jpg
fig6b.jpg
figs.hoc
find_averages.hoc
fixnseg.hoc
GaspiriniEtAl2007Fig1Stimulation.ses
generate_conc_graph.hoc
gka_averager.hoc
graph_na3_kinetics.hoc
init_and_run_and_graph.hoc
leaky_distal.hoc
maxica.hoc
maxica.ses.20100525
mosinit.hoc
na3_shifter.hoc
ntc_additions.hoc
oblique_application.hoc
oblique_scaled_ka.hoc
obliques_primary_tuft.hoc
paper_fig_buttons.hoc
sectiontest.hoc
shrink_obliques.hoc
SubBranch.hoc
trigger_and_start.hoc
wait_for_go.hoc
File not selected
<- Select file from this column.
Load Model Views
Figure 1, 2
Figure 3
Figure 4
Figure 5
Figure 6
Simulation Platform