MicrocircuitDB: Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)

Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)

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- c91662

Accession:87284

The model simulations provide evidence oblique dendrites in CA1 pyramidal neurons are susceptible to hyper-excitability by amyloid beta block of the transient K+ channel, IA. See paper for details.
Reference:
1 . Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM (2010) Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Front Neural Circuits [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Pathophysiology; Aging/Alzheimer`s;
Implementer(s):	Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu];

Search NeuronDB for information about: Hippocampus CA1 pyramidal GLU cell; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca;

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bAP_peak_vecs.hoc

C91662_Link.txt

cond_report.hoc

control_boxes.hoc

distribute_currents.hoc

fig2A_c91662.hoc

find_averages.hoc

GaspiriniEtAl2007Fig1Stimulation.ses

generate_conc_graph.hoc

gka_averager.hoc

graph_na3_kinetics.hoc

init_and_run_and_graph.hoc

leaky_distal.hoc

maxica.ses.20100525

na3_shifter.hoc

ntc_additions.hoc

oblique_application.hoc

oblique_scaled_ka.hoc

obliques_primary_tuft.hoc

paper_fig_buttons.hoc

sectiontest.hoc

shrink_obliques.hoc

trigger_and_start.hoc

wait_for_go.hoc

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