Classic model of the Tritonia Swim CPG (Getting, 1989)

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Accession:93326
Classic model developed by Petter Getting of the 3-cell core CPG (DSI, C2, and VSI-B) mediating escape swimming in Tritonia diomedea. Cells use a hybrid integrate-and-fire scheme pioneered by Peter Getting. Each model cell is reconstructed from extensive physiological measurements to precisely mimic I-F curves, synaptic waveforms, and functional connectivity. **However, continued physiological measurements show that Getting may have inadvertently incorporated modulatory and or polysynaptic effects -- the properties of this model do *not* match physiological measurements in rested preparations.** This simulation reconstructs the Getting model as reported in: Getting (1989) 'Reconstruction of small neural networks' In Methods in Neural Modeling, 1st ed, p. 171-196. See also, an earlier version of this model reported in Getting (1983). Every attempt has been made to replicate the 1989 model as precisely as possible.
Reference:
1 . Getting PA (1989) Reconstruction of small neural networks. Methods in Neuronal Modeling: From Synapses to Networks., Koch C:Segev I, ed. pp.171
2 . Getting PA (1983) Mechanisms of pattern generation underlying swimming in Tritonia. II. Network reconstruction. J Neurophysiol 49:1017-35 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Tritonia;
Cell Type(s): Tritonia swim interneuron dorsal; Tritonia cerebral cell; Tritonia swim interneuron ventral;
Channel(s): I A;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Oscillations; Invertebrate;
Implementer(s): Calin-Jageman, Robert [rcalinjageman at gsu dot edu];
Search NeuronDB for information about:  I A; 
: Leak Current Model, Bob Calin-Jageman 9/20/2002
: This model implements a simple leak function described by
: Getting, 1989 and utilized by Lieb and Frost, 1998.
: 
: 
: Created by Bob Calin-Jageman
: 
: Created 	9/20/2002
: Modified 	9/20/2002
: 
: Mathcheck  - Complete  9/31/2002
: Unitscheck - questions about resistance units
: 
: Explanation
: Leak current calculated as difference between current and resting membrane
: potentials divided by resistance
:	
: Resistance should be in megaOhms
: resting potential should be in millivolts
: output current will be in milliamps
: 
: References
: 	Getting, P.A. (1989) "Reconstruction of small neural networks" in 
: Methods in Neuronal Modeling: From Synapses to Networks (1st ed), Kock & Segev
: eds, MIT Press.

: 	Lieb JR & Frost WN (1997) "Realistic Simulation of the Aplysia Siphon
: Withdrawal Reflex Circuit: Roles of Circuit Elements in Producing Motor Output"
: p. 1249 */
: 
NEURON {
	POINT_PROCESS leak
	NONSPECIFIC_CURRENT i
	RANGE r, vrest
	}

UNITS {
	(mV) = (millivolt)
	(nA) = (nanoamp)
}

PARAMETER  {
	r = 15.7 (megaohm)
	vrest = -45 (mV)
	}

ASSIGNED {
	i	(nA)
	v	(mV)
	}


BREAKPOINT {
	i = (v - vrest)/r
	}