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CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
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NEURON mod files from N. Poolos, M. Migliore, and D. Johnston, Nature Neuroscience (2002). The experimental and modeling results in this paper demonstrate for the first time that neuronal excitability can be altered by pharmaceuticals acting selectively on dendrites, and suggest an important role for Ih in controlling dendritic excitability and epileptogenesis.
Poolos NP, Migliore M, Johnston D (2002) Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites.
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
Ion Channel Kinetics;
Detailed Neuronal Models;
Migliore, Michele [Michele.Migliore at Yale.edu];
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Hippocampus CA1 pyramidal GLU cell
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