Citations for CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)

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Miceli F, Soldovieri MV, Ambrosino P, Barrese V, Migliore M, Cilio MR, Taglialatela M (2013) Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of K(v)7.2 potassium channel subunits. Proc Natl Acad Sci U S A 110:4386-91 [PubMed]

References and models cited by this paper

References and models that cite this paper

Aggarwal SK, MacKinnon R (1996) Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron 16:1169-77 [PubMed]
Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK (1998) A potassium channel mutation in neonatal human epilepsy. Science 279:403-6 [PubMed]
Borgatti R, Zucca C, Cavallini A, Ferrario M, Panzeri C, Castaldo P, Soldovieri MV, Baschirotto C, Bresolin N, Dalla Bernardina B, Taglialatela M, Bassi MT (2004) A novel mutation in KCNQ2 associated with BFNC, drug resistant epilepsy, and mental retardation. Neurology 63:57-65 [PubMed]
Brown DA, Adams PR (1980) Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone. Nature 283:673-6 [PubMed]
Burley SK, Petsko GA (1985) Aromatic-aromatic interaction: a mechanism of protein structure stabilization. Science 229:23-8 [PubMed]
Castaldo P, del Giudice EM, Coppola G, Pascotto A, Annunziato L, Taglialatela M (2002) Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels. J Neurosci 22:RC199 [PubMed]
Chapman KE, Raol YH, Brooks-Kayal A (2012) Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette. Eur J Neurosci 35:1857-65 [Journal] [PubMed]
Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ, Leppert M (1998) A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet 18:53-5 [Journal] [PubMed]
Chung HJ, Jan YN, Jan LY (2006) Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc Natl Acad Sci U S A 103:8870-5 [Journal] [PubMed]
Cooper EC, Harrington E, Jan YN, Jan LY (2001) M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci 21:9529-40 [PubMed]
Dedek K, Fusco L, Teloy N, Steinlein OK (2003) Neonatal convulsions and epileptic encephalopathy in an Italian family with a missense mutation in the fifth transmembrane region of KCNQ2. Epilepsy Res 54:21-7
Dedek K, Kunath B, Kananura C, Reuner U, Jentsch TJ, Steinlein OK (2001) Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel. Proc Natl Acad Sci U S A 98:12272-7 [Journal] [PubMed]
Devaux JJ, Kleopa KA, Cooper EC, Scherer SS (2004) KCNQ2 is a nodal K+ channel. J Neurosci 24:1236-44 [Journal] [PubMed]
Glass HC, Glidden D, Jeremy RJ, Barkovich AJ, Ferriero DM, Miller SP (2009) Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury. J Pediatr 155:318-23 [Journal] [PubMed]
Gunthorpe MJ, Large CH, Sankar R (2012) The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy. Epilepsia 53:412-24 [Journal] [PubMed]
Hadley JK, Passmore GM, Tatulian L, Al-Qatari M, Ye F, Wickenden AD, Brown DA (2003) Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium. J Neurosci 23:5012-9 [PubMed]
Hermann R, Ferron GM, Erb K, Knebel N, Ruus P, Paul J, Richards L, Cnota HP, Troy S (2003) Effects of age and sex on the disposition of retigabine. Clin Pharmacol Ther 73:61-70 [Journal] [PubMed]
Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]
Long SB, Campbell EB, Mackinnon R (2005) Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science 309:903-8 [Journal] [PubMed]
Long SB, Tao X, Campbell EB, MacKinnon R (2007) Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature 450:376-82 [Journal] [PubMed]
Maljevic S, Wuttke TV, Lerche H (2008) Nervous system KV7 disorders: breakdown of a subthreshold brake. J Physiol 586:1791-801 [Journal] [PubMed]
Martire M, Castaldo P, D'Amico M, Preziosi P, Annunziato L, Taglialatela M (2004) M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. J Neurosci 24:592-7 [Journal] [PubMed]
Miceli F, Soldovieri MV, Hernandez CC, Shapiro MS, Annunziato L, Taglialatela M (2008) Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunit. Biophys J 95:2254-64 [Journal] [PubMed]
Miceli F, Soldovieri MV, Lugli L, Bellini G, Ambrosino P, Migliore M, del Giudice EM, Ferrari F, Pascotto A, Taglialatela M (2009) Neutralization of a unique, negatively-charged residue in the voltage sensor of K V 7.2 subunits in a sporadic case of benign familial neonatal seizures. Neurobiol Dis 34:501-10 [Journal] [PubMed]
  • CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009) [Model]
Miceli F, Vargas E, Bezanilla F, Taglialatela M (2012) Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain. Biophys J 102:1372-82 [Journal] [PubMed]
Migliore M, Morse TM, Davison AP, Marenco L, Shepherd GM, Hines ML (2003) ModelDB: making models publicly accessible to support computational neuroscience. Neuroinformatics 1:135-9 [Journal] [PubMed]
Nabbout R, Dulac O (2011) Epilepsy. Genetics of early-onset epilepsy with encephalopathy. Nat Rev Neurol 8:129-30
Painter MJ, Scher MS, Stein AD, Armatti S, Wang Z, Gardiner JC, Paneth N, Minnigh B, Alvin J (1999) Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med 341:485-9 [Journal] [PubMed]
Papazian DM, Shao XM, Seoh SA, Mock AF, Huang Y, Wainstock DH (1995) Electrostatic interactions of S4 voltage sensor in Shaker K+ channel. Neuron 14:1293-301 [PubMed]
Peretz A, Pell L, Gofman Y, Haitin Y, Shamgar L, Patrich E, Kornilov P, Gourgy-Hacohen O, Ben-Tal N, Attali B (2010) Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier. Proc Natl Acad Sci U S A 107:15637-42 [Journal] [PubMed]
Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D (2005) Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci 8:51-60 [Journal] [PubMed]
Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC (2009) A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol 65:326-36 [Journal] [PubMed]
Sadewa AH, Sasongko TH, Gunadi , Lee MJ, Daikoku K, Yamamoto A, Yamasaki T, Tanaka S, Matsuo M, Nishio H (2008) Germ-line mutation of KCNQ2, p.R213W, in a Japanese family with benign familial neonatal convulsion. Pediatr Int 50:167-71 [Journal] [PubMed]
Saitsu H, Kato M, Koide A, Goto T, Fujita T, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Hayasaka K, Matsumoto N (2012) Whole exome sequencing identifies KCNQ2 mutations in Ohtahara syndrome. Ann Neurol 72:298-300 [Journal] [PubMed]
Sankar R, Painter MJ (2005) Neonatal seizures: after all these years we still love what doesn't work. Neurology 64:776-7 [Journal] [PubMed]
Schwarz JR, Glassmeier G, Cooper EC, Kao TC, Nodera H, Tabuena D, Kaji R, Bostock H (2006) KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. J Physiol 573:17-34 [Journal] [PubMed]
Schwede T, Kopp J, Guex N, Peitsch MC (2003) SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Res 31:3381-5 [PubMed]
Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA (2008) Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A 105:7869-74 [Journal] [PubMed]
  • CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008) [Model]
Soldovieri MV, Castaldo P, Iodice L, Miceli F, Barrese V, Bellini G, Miraglia del Giudice E, Pascotto A, Bonatti S, Annunziato L, Taglialatela M (2006) Decreased subunit stability as a novel mechanism for potassium current impairment by a KCNQ2 C terminus mutation causing benign familial neonatal convulsions. J Biol Chem 281:418-28 [Journal] [PubMed]
Soldovieri MV, Miceli F, Taglialatela M (2011) Driving with no brakes: molecular pathophysiology of Kv7 potassium channels. Physiology (Bethesda) 26:365-76 [Journal] [PubMed]
Steinlein OK, Conrad C, Weidner B (2007) Benign familial neonatal convulsions: always benign? Epilepsy Res 73:245-9 [Journal] [PubMed]
Stewart AP, Gómez-Posada JC, McGeorge J, Rouhani MJ, Villarroel A, Murrell-Lagnado RD, Edwardson JM (2012) The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement. J Biol Chem 287:11870-7 [Journal] [PubMed]
Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282:1890-3 [PubMed]
Wuttke TV, Penzien J, Fauler M, Seebohm G, Lehmann-Horn F, Lerche H, Jurkat-Rott K (2008) Neutralization of a negative charge in the S1-S2 region of the KV7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy. J Physiol 586:545-55 [Journal] [PubMed]
Cavarretta F, Carnevale NT, Tegolo D, Migliore M (2014) Effects of low frequency electric fields on synaptic integration in hippocampal CA1 pyramidal neurons: implications for power line emissions. Front Cell Neurosci 8:310 [Journal] [PubMed]
  • CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014) [Model]
Miceli F, Soldovieri MV, Ambrosino P, De Maria M, Migliore M, Migliore R, Taglialatela M (2015) Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits. J Neurosci 35:3782-93 [Journal] [PubMed]
  • Early-onset epileptic encephalopathy (Miceli et al. 2015) [Model]
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