Citations for Single compartment: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)

Legends: Link to a Model Reference cited by multiple papers


Schulz JM, Knoflach F, Hernandez MC, Bischofberger J (2018) Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear a5-GABAA receptors. Nat Commun 9:3576 [PubMed]

References and models cited by this paper

References and models that cite this paper

Ali AB, Thomson AM (2008) Synaptic alpha 5 subunit-containing GABAA receptors mediate IPSPs elicited by dendrite-preferring cells in rat neocortex. Cereb Cortex 18:1260-71 [Journal] [PubMed]
Armstrong C, Krook-Magnuson E, Soltesz I (2012) Neurogliaform and Ivy Cells: A Major Family of nNOS Expressing GABAergic Neurons. Front Neural Circuits 6:23 [Journal] [PubMed]
Ballard TM, Knoflach F, Prinssen E, Borroni E, Vivian JA, Basile J, Gasser R, Moreau JL, Wettstein JG, Buettelmann B, Knust H, Thomas AW, Trube G, Hernandez MC (2009) RO4938581, a novel cognitive enhancer acting at GABAA alpha5 subunit-containing receptors. Psychopharmacology (Berl) 202:207-23 [Journal] [PubMed]
Bartos M, Vida I, Jonas P (2007) Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks. Nat Rev Neurosci 8:45-56 [Journal] [PubMed]
Bezaire MJ, Raikov I, Burk K, Vyas D, Soltesz I (2016) Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit. Elife [Journal] [PubMed]
  • Hippocampal CA1 NN with spontaneous theta, gamma: full scale & network clamp (Bezaire et al 2016) [Model]
Bischofberger J, Engel D, Li L, Geiger JR, Jonas P (2006) Patch-clamp recording from mossy fiber terminals in hippocampal slices. Nat Protoc 1:2075-81 [Journal] [PubMed]
Bittner KC, Grienberger C, Vaidya SP, Milstein AD, Macklin JJ, Suh J, Tonegawa S, Magee JC (2015) Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons. Nat Neurosci 18:1133-42 [Journal] [PubMed]
Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N (2016) Structured Dendritic Inhibition Supports Branch-Selective Integration in CA1 Pyramidal Cells. Neuron 89:1016-30 [Journal] [PubMed]
  • CA1 pyramidal neuron synaptic integration (Bloss et al. 2016) [Model]
Braat S, Kooy RF (2015) The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders. Neuron 86:1119-30 [Journal] [PubMed]
Brady ML, Jacob TC (2015) Synaptic localization of a5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation. Dev Neurobiol 75:1241-51 [Journal] [PubMed]
Brickley SG, Mody I (2012) Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease. Neuron 73:23-34 [Journal] [PubMed]
Capogna M, Pearce RA (2011) GABA A,slow: causes and consequences. Trends Neurosci 34:101-12 [Journal] [PubMed]
Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, MacDonald JF, Orser BA (2004) Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A 101:3662-7 [Journal] [PubMed]
Cichon J, Blanck TJJ, Gan WB, Yang G (2017) Activation of cortical somatostatin interneurons prevents the development of neuropathic pain. Nat Neurosci 20:1122-1132 [Journal] [PubMed]
Cichon J, Gan WB (2015) Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity. Nature 520:180-5 [Journal] [PubMed]
Collinson N, Kuenzi FM, Jarolimek W, Maubach KA, Cothliff R, Sur C, Smith A, Otu FM, Howell O, Atack JR, McKernan RM, Seabrook GR, Dawson GR, Whiting PJ, Rosahl TW (2002) Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor. J Neurosci 22:5572-80 [Journal] [PubMed]
Farrant M, Nusser Z (2005) Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci 6:215-29 [Journal] [PubMed]
Fischell J, Van Dyke AM, Kvarta MD, LeGates TA, Thompson SM (2015) Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors. Neuropsychopharmacology 40:2499-509 [Journal] [PubMed]
Fritschy JM, Mohler H (1995) GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154-94 [Journal] [PubMed]
Geiger JR, Bischofberger J, Vida I, Fröbe U, Pfitzinger S, Weber HJ, Haverkampf K, Jonas P (2002) Patch-clamp recording in brain slices with improved slicer technology. Pflugers Arch 443:491-501 [Journal] [PubMed]
Gentet LJ, Kremer Y, Taniguchi H, Huang ZJ, Staiger JF, Petersen CC (2012) Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex. Nat Neurosci 15:607-12 [Journal] [PubMed]
Glykys J, Mody I (2007) The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J Physiol 582:1163-78 [Journal] [PubMed]
Guzman SJ, Schlögl A, Schmidt-Hieber C (2014) Stimfit: quantifying electrophysiological data with Python. Front Neuroinform 8:16 [Journal] [PubMed]
Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]
Hu H, Gan J, Jonas P (2014) Interneurons. Fast-spiking, parvalbumin? GABAergic interneurons: from cellular design to microcircuit function. Science 345:1255263 [Journal] [PubMed]
Jahr CE, Stevens CF (1990) Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics. J Neurosci 10:3178-82 [PubMed]
Jonas P, Bischofberger J, Fricker D, Miles R (2004) Interneuron Diversity series: Fast in, fast out--temporal and spatial signal processing in hippocampal interneurons. Trends Neurosci 27:30-40 [Journal] [PubMed]
Kapfer C, Glickfeld LL, Atallah BV, Scanziani M (2007) Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. Nat Neurosci 10:743-53 [Journal] [PubMed]
Kapur A, Lytton WW, Ketchum KL, Haberly LB (1997) Regulation of the NMDA component of EPSPs by different components of postsynaptic GABAergic inhibition: computer simulation analysis in piriform cortex. J Neurophysiol 78:2546-59 [Journal] [PubMed]
Kirizs T, Kerti-Szigeti K, Lorincz A, Nusser Z (2014) Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells. Eur J Neurosci 39:1771-83 [Journal] [PubMed]
Klausberger T, Somogyi P (2008) Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science 321:53-7 [Journal] [PubMed]
Larkum ME, Nevian T, Sandler M, Polsky A, Schiller J (2009) Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. Science 325:756-60 [Journal] [PubMed]
  • Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009) [Model]
Lee S, Kruglikov I, Huang ZJ, Fishell G, Rudy B (2013) A disinhibitory circuit mediates motor integration in the somatosensory cortex. Nat Neurosci 16:1662-70 [Journal] [PubMed]
Lovett-Barron M, Turi GF, Kaifosh P, Lee PH, Bolze F, Sun XH, Nicoud JF, Zemelman BV, Sternson SM, Losonczy A (2012) Regulation of neuronal input transformations by tunable dendritic inhibition. Nat Neurosci 15:423-30, S1-3 [Journal] [PubMed]
Maccaferri G, Roberts JD, Szucs P, Cottingham CA, Somogyi P (2000) Cell surface domain specific postsynaptic currents evoked by identified GABAergic neurones in rat hippocampus in vitro. J Physiol 524 Pt 1:91-116 [PubMed]
Major G, Larkum ME, Schiller J (2013) Active properties of neocortical pyramidal neuron dendrites. Annu Rev Neurosci 36:1-24 [Journal] [PubMed]
Martin LJ, Zurek AA, MacDonald JF, Roder JC, Jackson MF, Orser BA (2010) Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. J Neurosci 30:5269-82 [Journal] [PubMed]
Martínez-Cué C, Martínez P, Rueda N, Vidal R, García S, Vidal V, Corrales A, Montero JA, Pazos Á, Flórez J, Gasser R, Thomas AW, Honer M, Knoflach F, Trejo JL, Wettstein JG, Hernández MC (2013) Reducing GABAA a5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome. J Neurosci 33:3953-66 [Journal] [PubMed]
Mendez MA, Horder J, Myers J, Coghlan S, Stokes P, Erritzoe D, Howes O, Lingford-Hughes A, Murphy D, Nutt D (2013) The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography study. Neuropharmacology 68:195-201 [Journal] [PubMed]
Migliore M, Messineo L, Ferrante M (2004) Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons. J Comput Neurosci 16:5-13 [PubMed]
  • CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004) [Model]
Möhler H, Rudolph U (2017) Disinhibition, an emerging pharmacology of learning and memory. F1000Res [Journal] [PubMed]
Palmer LM, Shai AS, Reeve JE, Anderson HL, Paulsen O, Larkum ME (2014) NMDA spikes enhance action potential generation during sensory input. Nat Neurosci 17:383-90 [Journal] [PubMed]
Pavlov I, Savtchenko LP, Kullmann DM, Semyanov A, Walker MC (2009) Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain. J Neurosci 29:15341-50 [Journal] [PubMed]
Petreanu L, Huber D, Sobczyk A, Svoboda K (2007) Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nat Neurosci 10:663-8 [Journal] [PubMed]
Petreanu L, Mao T, Sternson SM, Svoboda K (2009) The subcellular organization of neocortical excitatory connections. Nature 457:1142-5 [Journal] [PubMed]
Pi HJ, Hangya B, Kvitsiani D, Sanders JI, Huang ZJ, Kepecs A (2013) Cortical interneurons that specialize in disinhibitory control. Nature 503:521-4 [Journal] [PubMed]
Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G (2000) GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101:815-50 [PubMed]
Poirazi P, Brannon T, Mel BW (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-87 [PubMed]
  • CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003) [Model]
Prenosil GA, Schneider Gasser EM, Rudolph U, Keist R, Fritschy JM, Vogt KE (2006) Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons. J Neurophysiol 96:846-57 [Journal] [PubMed]
Quirk K, Blurton P, Fletcher S, Leeson P, Tang F, Mellilo D, Ragan CI, McKernan RM (1996) [3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the alpha 5 subunit. Neuropharmacology 35:1331-5 [Journal] [PubMed]
Robertson CE, Ratai EM, Kanwisher N (2016) Reduced GABAergic Action in the Autistic Brain. Curr Biol 26:80-5 [Journal] [PubMed]
Royer S, Zemelman BV, Losonczy A, Kim J, Chance F, Magee JC, Buzsáki G (2012) Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition. Nat Neurosci 15:769-75 [Journal] [PubMed]
Rudolph U, Knoflach F (2011) Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nat Rev Drug Discov 10:685-97 [Journal] [PubMed]
Serwanski DR, Miralles CP, Christie SB, Mehta AK, Li X, De Blas AL (2006) Synaptic and nonsynaptic localization of GABAA receptors containing the alpha5 subunit in the rat brain. J Comp Neurol 499:458-70 [Journal] [PubMed]
Silberberg G, Markram H (2007) Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells. Neuron 53:735-46 [Journal] [PubMed]
Soh MS, Lynch JW (2015) Selective Modulators of a5-Containing GABAA Receptors and their Therapeutic Significance. Curr Drug Targets 16:735-46 [PubMed]
Somogyi P, Katona L, Klausberger T, Lasztóczi B, Viney TJ (2014) Temporal redistribution of inhibition over neuronal subcellular domains underlies state-dependent rhythmic change of excitability in the hippocampus. Philos Trans R Soc Lond B Biol Sci 369:20120518 [Journal] [PubMed]
Takahashi H, Magee JC (2009) Pathway interactions and synaptic plasticity in the dendritic tuft regions of CA1 pyramidal neurons. Neuron 62:102-11 [Journal] [PubMed]
Vargas-Caballero M, Martin LJ, Salter MW, Orser BA, Paulsen O (2010) alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation. Neuropharmacology 58:668-75 [Journal] [PubMed]
Wilson NR, Runyan CA, Wang FL, Sur M (2012) Division and subtraction by distinct cortical inhibitory networks in vivo. Nature 488:343-8 [Journal] [PubMed]
Zanos P, Nelson ME, Highland JN, Krimmel SR, Georgiou P, Gould TD, Thompson SM (2017) A Negative Allosteric Modulator for a5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice. eNeuro [Journal] [PubMed]
Zarnowska ED, Keist R, Rudolph U, Pearce RA (2009) GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus. J Neurophysiol 101:1179-91 [Journal] [PubMed]
Zurek AA, Kemp SW, Aga Z, Walker S, Milenkovic M, Ramsey AJ, Sibille E, Scherer SW, Orser BA (2016) a5GABAA receptor deficiency causes autism-like behaviors. Ann Clin Transl Neurol 3:392-8 [Journal] [PubMed]
(64 refs)