Citation Relationships

Legends: Link to a Model Reference cited by multiple papers


Moroni M, Biro I, Giugliano M, Vijayan R, Biggin PC, Beato M, Sivilotti LG (2011) Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents. J Neurosci 31:14095-106 [PubMed]

   Pipette and membrane patch geometry effects on GABAa currents patch-clamp exps (Moroni et al. 2011)

References and models cited by this paper

References and models that cite this paper

Adam G, Leuger P, Stark G (2007) Physikalische Chemie und Biophysik
Adams DJ, Gage PW, Hamill OP (1982) Inhibitory postsynaptic currents at Aplysia cholinergic synapses: effects of permeant anions and depressant drugs. Proc R Soc Lond B Biol Sci 214:335-50 [Journal] [PubMed]
Ascher P, Marty A, Neild TO (1978) Life time and elementary conductance of the channels mediating the excitatory effects of acetylcholine in Aplysia neurones. J Physiol 278:177-206 [PubMed]
Baker NA, Sept D, Joseph S, Holst MJ, McCammon JA (2001) Electrostatics of nanosystems: application to microtubules and the ribosome. Proc Natl Acad Sci U S A 98:10037-41 [Journal] [PubMed]
Beato M, Groot-Kormelink PJ, Colquhoun D, Sivilotti LG (2002) Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound. J Gen Physiol 119:443-66 [PubMed]
Bocquet N, Nury H, Baaden M, Le Poupon C, Changeux JP, Delarue M, Corringer PJ (2009) X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature 457:111-4 [Journal] [PubMed]
Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ (2007) A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature 445:116-9 [Journal] [PubMed]
Bormann J, Hamill OP, Sakmann B (1987) Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J Physiol 385:243-86 [PubMed]
Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2003) Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation. Receptors Channels 9:353-61 [PubMed]
Cannell MB, Nichols CG (1991) Effects of pipette geometry on the time course of solution change in patch clamp experiments. Biophys J 60:1156-63 [Journal] [PubMed]
Carland JE, Cooper MA, Sugiharto S, Jeong HJ, Lewis TM, Barry PH, Peters JA, Lambert JJ, Moorhouse AJ (2009) Characterization of the effects of charged residues in the intracellular loop on ion permeation in alpha1 glycine receptor channels. J Biol Chem 284:2023-30 [Journal] [PubMed]
Clements JD (1996) Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci 19:163-71 [PubMed]
Cymes GD, Ni Y, Grosman C (2005) Probing ion-channel pores one proton at a time. Nature 438:975-80 [Journal] [PubMed]
Edgar RC (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 32:1792-7 [Journal] [PubMed]
Edmonds B, Gibb AJ, Colquhoun D (1995) Mechanisms of activation of muscle nicotinic acetylcholine receptors and the time course of endplate currents. Annu Rev Physiol 57:469-93 [Journal] [PubMed]
Goodford PJ (1985) A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. J Med Chem 28:849-57 [PubMed]
Groot-Kormelink PJ, Beato M, Finotti C, Harvey RJ, Sivilotti LG (2002) Achieving optimal expression for single channel recording: a plasmid ratio approach to the expression of alpha 1 glycine receptors in HEK293 cells. J Neurosci Methods 113:207-14 [PubMed]
Hansen SB, Wang HL, Taylor P, Sine SM (2008) An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance. J Biol Chem 283:36066-70 [Journal] [PubMed]
Hibbs RE, Gouaux E (2011) Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature 474:54-60 [Journal] [PubMed]
Hilf RJ, Dutzler R (2008) X-ray structure of a prokaryotic pentameric ligand-gated ion channel. Nature 452:375-9 [Journal] [PubMed]
Hilf RJ, Dutzler R (2009) Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel. Nature 457:115-8 [Journal] [PubMed]
Hines ML, Morse T, Migliore M, Carnevale NT, Shepherd GM (2004) ModelDB: A Database to Support Computational Neuroscience. J Comput Neurosci 17:7-11 [Journal] [PubMed]
Houston CM, Bright DP, Sivilotti LG, Beato M, Smart TG (2009) Intracellular chloride ions regulate the time course of GABA-mediated inhibitory synaptic transmission. J Neurosci 29:10416-23 [Journal] [PubMed]
Ivanov I, Cheng X, Sine SM, McCammon JA (2007) Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family. J Am Chem Soc 129:8217-24 [Journal] [PubMed]
Jansen M, Bali M, Akabas MH (2008) Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop. J Gen Physiol 131:137-46 [Journal] [PubMed]
Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (2003) A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. Nature 424:321-4 [Journal] [PubMed]
Keramidas A, Moorhouse AJ, French CR, Schofield PR, Barry PH (2000) M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective. Biophys J 79:247-59 [Journal] [PubMed]
Keramidas A, Moorhouse AJ, Pierce KD, Schofield PR, Barry PH (2002) Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity. J Gen Physiol 119:393-410 [PubMed]
Langosch D, Herbold A, Schmieden V, Borman J, Kirsch J (1993) Importance of Arg-219 for correct biogenesis of alpha 1 homooligomeric glycine receptors. FEBS Lett 336:540-4 [PubMed]
Langosch D, Laube B, Rundström N, Schmieden V, Bormann J, Betz H (1994) Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia. EMBO J 13:4223-8 [PubMed]
Laskowski RA, Macarthur MW, Moss DS, Thornton JM (1993) PROCHECK:a program to check the stereochemical quality of protein structures J Appl Cryst 26:283-291
Legendre P (1999) Voltage dependence of the glycine receptor-channel kinetics in the zebrafish hindbrain. J Neurophysiol 82:2120-9 [Journal] [PubMed]
Lewis TM, Sivilotti LG, Colquhoun D, Gardiner RM, Schoepfer R, Rees M (1998) Properties of human glycine receptors containing the hyperekplexia mutation 1(K276E), expressed in Xenopus oocytes J Physiol 507:25-40
Lindahl E, Hess B, Van_der_spoel D (2001) GROMACS 3.0: a package for molecular simulation and trajectory analysis J Mol Mod 7:306-317
Lobo vm, Ribeiro ac , Verissimo lm (1998) Diffusion coefficients in aqueous solutions of potassium chloride at high and low concentrations J Mol Liq 78:139-149
Lynch JW, Rajendra S, Pierce KD, Handford CA, Barry PH, Schofield PR (1997) Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel. EMBO J 16:110-20 [Journal] [PubMed]
Magleby KL, Stevens CF (1972) The effect of voltage on the time course of end-plate currents. J Physiol 223:151-71 [PubMed]
Marchais D, Marty A (1979) Interaction of permeant ions with channels activated by acetylcholine in Aplysia neurones. J Physiol 297:9-45 [PubMed]
Moroni M, Meyer JO, Lahmann C, Sivilotti LG (2011) In glycine and GABA(A) channels, different subunits contribute asymmetrically to channel conductance via residues in the extracellular domain. J Biol Chem 286:13414-22 [Journal] [PubMed]
O'Mara M, Cromer B, Parker M, Chung SH (2005) Homology model of the GABAA receptor examined using Brownian dynamics. Biophys J 88:3286-99 [Journal] [PubMed]
Oliva C, Cohen IS, Mathias RT (1988) Calculation of time constants for intracellular diffusion in whole cell patch clamp configuration. Biophys J 54:791-9 [Journal] [PubMed]
Onodera K, Takeuchi A (1979) An analysis of the inhibitory post-synaptic current in the voltage-clamped crayfish muscle. J Physiol 286:265-82 [PubMed]
Paas Y, Gibor G, Grailhe R, Savatier-Duclert N, Dufresne V, Sunesen M, de Carvalho LP, Changeux JP, Attali B (2005) Pore conformations and gating mechanism of a Cys-loop receptor. Proc Natl Acad Sci U S A 102:15877-82 [Journal] [PubMed]
Peters JA, Cooper MA, Carland JE, Livesey MR, Hales TG, Lambert JJ (2010) Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors. J Physiol 588:587-96 [Journal] [PubMed]
Pitt SJ, Sivilotti LG, Beato M (2008) High intracellular chloride slows the decay of glycinergic currents. J Neurosci 28:11454-67 [Journal] [PubMed]
Pittel I, Witt-Kehati D, Degani-Katzav N, Paas Y (2010) Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation. J Biol Chem 285:26519-31 [Journal] [PubMed]
Press WH, Flannery BP, Teukolsky SA (1992) Numerical recipes in C: The Art of Scientific Computing, 2nd edn
Rea R, Tijssen MA, Herd C, Frants RR, Kullmann DM (2002) Functional characterization of compound heterozygosity for GlyRalpha1 mutations in the startle disease hyperekplexia. Eur J Neurosci 16:186-96 [PubMed]
Sali A, Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234:779-815 [Journal] [PubMed]
Shiang R, Ryan SG, Zhu YZ, Hahn AF, O'Connell P, Wasmuth JJ (1993) Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia. Nat Genet 5:351-8 [Journal] [PubMed]
Song C, Corry B (2010) Ion conduction in ligand-gated ion channels: Brownian dynamics studies of four recent crystal structures. Biophys J 98:404-11 [Journal] [PubMed]
Unwin N (2005) Refined structure of the nicotinic acetylcholine receptor at 4A resolution. J Mol Biol 346:967-89 [Journal] [PubMed]
Van Helden D, Hamill OP, Gage PW (1977) Permeant cations alter endplate channel characteristics. Nature 269:711-3 [PubMed]
VanGunsteren WF, Billeter sr, Eising AA, Kruger P, Scott wr, Tironi IG (1996) Biomolecular Simulation: the GROMOS96 manual and user guide
Wyllie DJ, Béhé P, Colquhoun D (1998) Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors. J Physiol 510 ( Pt 1):1-18 [PubMed]
Xu M, Akabas MH (1993) Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution. J Biol Chem 268:21505-8 [PubMed]
Xu M, Akabas MH (1996) Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit. J Gen Physiol 107:195-205 [PubMed]
(58 refs)