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Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO (2013) A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol 591:1771-91 [PubMed]

   KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)

References and models cited by this paper

References and models that cite this paper

Aizenman CD, Linden DJ (1999) Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. J Neurophysiol 82:1697-709 [Journal] [PubMed]
Akhtar S, Shamotienko O, Papakosta M, Ali F, Dolly JO (2002) Characteristics of brain Kv1 channels tailored to mimic native counterparts by tandem linkage of alpha subunits: implications for K+ channelopathies. J Biol Chem 277:16376-82 [Journal] [PubMed]
Al-Sabi A, Shamotienko O, Dhochartaigh SN, Muniyappa N, Le Berre M, Shaban H, Wang J, Sack JT, Dolly JO (2010) Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J Gen Physiol 136:273-82 [Journal] [PubMed]
Apps R, Garwicz M (2005) Anatomical and physiological foundations of cerebellar information processing. Nat Rev Neurosci 6:297-311 [Journal] [PubMed]
Archer SL, London B, Hampl V, Wu X, Nsair A, Puttagunta L, Hashimoto K, Waite RE, Michelakis ED (2001) Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. FASEB J 15:1801-3 [PubMed]
Baranauskas G, Tkatch T, Nagata K, Yeh JZ, Surmeier DJ (2003) Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons. Nat Neurosci 6:258-66 [Journal] [PubMed]
Baranauskas G, Tkatch T, Surmeier DJ (1999) Delayed rectifier currents in rat globus pallidus neurons are attributable to Kv2.1 and Kv3.1/3.2 K(+) channels. J Neurosci 19:6394-404 [PubMed]
Brew HM, Gittelman JX, Silverstein RS, Hanks TD, Demas VP, Robinson LC, Robbins CA, McKee-Johnson J, Chiu SY, Messing A, Tempel BL (2007) Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons. J Neurophysiol 98:1501-25 [Journal] [PubMed]
Chacron MJ, Longtin A, Maler L (2003) The effects of spontaneous activity, background noise, and the stimulus ensemble on information transfer in neurons. Network 14:803-24 [PubMed]
Chacron MJ, Pakdaman K, Longtin A (2003) Interspike interval correlations, memory, adaptation, and refractoriness in a leaky integrate-and-fire model with threshold fatigue. Neural Comput 15:253-78 [Journal] [PubMed]
Chung YH, Joo KM, Nam RH, Kim YS, Lee WB, Cha CI (2005) Immunohistochemical study on the distribution of the voltage-gated potassium channels in the gerbil cerebellum. Neurosci Lett 374:58-62 [Journal] [PubMed]
Clark BD, Goldberg EM, Rudy B (2009) Electrogenic tuning of the axon initial segment. Neuroscientist 15:651-68 [Journal] [PubMed]
Coleman SK, Newcombe J, Pryke J, Dolly JO (1999) Subunit composition of Kv1 channels in human CNS. J Neurochem 73:849-58 [PubMed]
COOMBS JS, CURTIS DR, ECCLES JC (1957) The interpretation of spike potentials of motoneurones. J Physiol 139:198-231 [PubMed]
De Schutter E, Steuber V (2009) Patterns and pauses in Purkinje cell simple spike trains: experiments, modeling and theory. Neuroscience 162:816-26 [Journal] [PubMed]
Dodson PD, Barker MC, Forsythe ID (2002) Two heteromeric Kv1 potassium channels differentially regulate action potential firing. J Neurosci 22:6953-61 [Journal] [PubMed]
Dodson PD, Billups B, Rusznák Z, Szûcs G, Barker MC, Forsythe ID (2003) Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion. J Physiol 550:27-33 [Journal] [PubMed]
Dolly JO, Rettig J, Scott VE, Parcej DN, Wittkat R, Sewing S, Pongs O (1994) Oligomeric and subunit structures of neuronal voltage-sensitive K+ channels. Biochem Soc Trans 22:473-8 [PubMed]
Eccles JC (1973) The cerebellum as a computer: patterns in space and time. J Physiol 229:1-32 [PubMed]
Gauck V, Jaeger D (2000) The control of rate and timing of spikes in the deep cerebellar nuclei by inhibition. J Neurosci 20:3006-16 [PubMed]
Goldberg EM, Clark BD, Zagha E, Nahmani M, Erisir A, Rudy B (2008) K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons. Neuron 58:387-400 [Journal] [PubMed]
Häusser M, Clark BA (1997) Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron 19:665-78 [PubMed]
Heinemann S, Rettig J, Scott V, Parcej DN, Lorra C, Dolly J, Pongs O (1994) The inactivation behaviour of voltage-gated K-channels may be determined by association of alpha- and beta-subunits. J Physiol Paris 88:173-80 [PubMed]
Herson PS, Virk M, Rustay NR, Bond CT, Crabbe JC, Adelman JP, Maylie J (2003) A mouse model of episodic ataxia type-1. Nat Neurosci 6:378-83 [Journal] [PubMed]
Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]
Hopkins WF (1998) Toxin and subunit specificity of blocking affinity of three peptide toxins for heteromultimeric, voltage-gated potassium channels expressed in Xenopus oocytes. J Pharmacol Exp Ther 285:1051-60 [PubMed]
Ito M (1984) The Cerebellum And Neural Control
Ito M (2006) Cerebellar circuitry as a neuronal machine. Prog Neurobiol 78:272-303 [Journal] [PubMed]
Jahnsen H (1986) Electrophysiological characteristics of neurones in the guinea-pig deep cerebellar nuclei in vitro. J Physiol 372:129-47 [PubMed]
Jahnsen H (1986) Extracellular activation and membrane conductances of neurones in the guinea-pig deep cerebellar nuclei in vitro. J Physiol 372:149-68 [PubMed]
Khavandgar S, Walter JT, Sageser K, Khodakhah K (2005) Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells. J Physiol 569:545-57 [Journal] [PubMed]
Kleim JA, Swain RA, Armstrong KA, Napper RM, Jones TA, Greenough WT (1998) Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning. Neurobiol Learn Mem 69:274-89 [Journal] [PubMed]
Kullmann DM, Rea R, Spauschus A, Jouvenceau A (2001) The inherited episodic ataxias: how well do we understand the disease mechanisms? Neuroscientist 7:80-8 [Journal] [PubMed]
Llinás R, Mühlethaler M (1988) Electrophysiology of guinea-pig cerebellar nuclear cells in the in vitro brain stem-cerebellar preparation. J Physiol 404:241-58 [PubMed]
Locke RE, Nerbonne JM (1997) Role of voltage-gated K+ currents in mediating the regular-spiking phenotype of callosal-projecting rat visual cortical neurons. J Neurophysiol 78:2321-35 [Journal] [PubMed]
London B, Wang DW, Hill JA, Bennett PB (1998) The transient outward current in mice lacking the potassium channel gene Kv1.4. J Physiol 509 ( Pt 1):171-82 [PubMed]
Manganas LN, Trimmer JS (2000) Subunit composition determines Kv1 potassium channel surface expression. J Biol Chem 275:29685-93 [Journal] [PubMed]
McCormack K, Connor JX, Zhou L, Ho LL, Ganetzky B, Chiu SY, Messing A (2002) Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2). J Biol Chem 277:13219-28 [Journal] [PubMed]
McKay BE, Molineux ML, Mehaffey WH, Turner RW (2005) Kv1 K+ channels control Purkinje cell output to facilitate postsynaptic rebound discharge in deep cerebellar neurons. J Neurosci 25:1481-92 [Journal] [PubMed]
McNamara NM, Muniz ZM, Wilkin GP, Dolly JO (1993) Prominent location of a K+ channel containing the alpha subunit Kv 1.2 in the basket cell nerve terminals of rat cerebellum. Neuroscience 57:1039-45 [PubMed]
Ovsepian SV, Friel DD (2008) The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts. Eur J Neurosci 27:93-103 [Journal] [PubMed]
Ovsepian SV, Friel DD (2012) Enhanced synaptic inhibition disrupts the efferent code of cerebellar Purkinje neurons in leaner Cav2.1 Ca 2+ channel mutant mice. Cerebellum 11:666-80 [Journal] [PubMed]
Pongs O (1999) Voltage-gated potassium channels: from hyperexcitability to excitement. FEBS Lett 452:31-5 [PubMed]
Raman IM, Gustafson AE, Padgett D (2000) Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei. J Neurosci 20:9004-16 [PubMed]
Rasband MN, Shrager P (2000) Ion channel sequestration in central nervous system axons. J Physiol 525 Pt 1:63-73 [PubMed]
Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO, Pongs O (1994) Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Nature 369:289-94 [Journal] [PubMed]
Rudy B, McBain CJ (2001) Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing. Trends Neurosci 24:517-26 [PubMed]
Sack JT, Shamotienko O, Dolly JO (2008) How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits. J Gen Physiol 131:415-20 [Journal] [PubMed]
Sastry BR, Morishita W, Yip S, Shew T (1997) GABA-ergic transmission in deep cerebellar nuclei. Prog Neurobiol 53:259-71 [PubMed]
Scott VE, Muniz ZM, Sewing S, Lichtinghagen R, Parcej DN, Pongs O, Dolly JO (1994) Antibodies specific for distinct Kv subunits unveil a heterooligomeric basis for subtypes of alpha-dendrotoxin-sensitive K+ channels in bovine brain. Biochemistry 33:1617-23 [PubMed]
Scott VE, Rettig J, Parcej DN, Keen JN, Findlay JB, Pongs O, Dolly JO (1994) Primary structure of a beta subunit of alpha-dendrotoxin-sensitive K+ channels from bovine brain. Proc Natl Acad Sci U S A 91:1637-41 [PubMed]
Shamotienko OG, Parcej DN, Dolly JO (1997) Subunit combinations defined for K+ channel Kv1 subtypes in synaptic membranes from bovine brain. Biochemistry 36:8195-201 [Journal] [PubMed]
Shi G, Nakahira K, Hammond S, Rhodes KJ, Schechter LE, Trimmer JS (1996) Beta subunits promote K+ channel surface expression through effects early in biosynthesis. Neuron 16:843-52 [PubMed]
Smart SL, Lopantsev V, Zhang CL, Robbins CA, Wang H, Chiu SY, Schwartzkroin PA, Messing A, Tempel BL (1998) Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron 20:809-19 [PubMed]
Steuber V, De Schutter E, Jaeger D (2004) Passive models of neurons in the deep cerebellar nuclei: the effect of reconstruction errors Neurocomputing 58-60:563-568 [Journal]
   Robust transmission in the inhibitory Purkinje Cell to Cerebellar Nuclei pathway (Abbasi et al 2017) [Model]
Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D (2011) Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. J Comput Neurosci 30:633-58 [Journal] [PubMed]
   Cerebellar Nucleus Neuron (Steuber, Schultheiss, Silver, De Schutter & Jaeger, 2010) [Model]
   Robust transmission in the inhibitory Purkinje Cell to Cerebellar Nuclei pathway (Abbasi et al 2017) [Model]
Stuart G, Spruston N, Sakmann B, Häusser M (1997) Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci 20:125-31 [PubMed]
Stühmer W, Ruppersberg JP, Schröter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, Pongs O (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J 8:3235-44 [PubMed]
Thach WT (1968) Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey. J Neurophysiol 31:785-97 [Journal] [PubMed]
Uhlenbeck GE, Ornstein LS (1930) On the theory of Brownian motion Phys Rev 36:823-841 [Journal]
Uusisaari M, De Schutter E (2011) The mysterious microcircuitry of the cerebellar nuclei. J Physiol 589:3441-57 [Journal] [PubMed]
Vacher H, Mohapatra DP, Trimmer JS (2008) Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev 88:1407-47 [Journal] [PubMed]
Walter JT, Alviña K, Womack MD, Chevez C, Khodakhah K (2006) Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nat Neurosci 9:389-97 [Journal] [PubMed]
Wang H, Kunkel DD, Martin TM, Schwartzkroin PA, Tempel BL (1993) Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons. Nature 365:75-9 [Journal] [PubMed]
Xie G, Harrison J, Clapcote SJ, Huang Y, Zhang JY, Wang LY, Roder JC (2010) A new Kv1.2 channelopathy underlying cerebellar ataxia. J Biol Chem 285:32160-73 [Journal] [PubMed]
Xu C, Tang G, Lu Y, Wang R (2000) Molecular basis of voltage-dependent delayed rectifier K+ channels in smooth muscle cells from rat tail artery. Life Sci 66:2023-33 [PubMed]
Zhang CL, Messing A, Chiu SY (1999) Specific alteration of spontaneous GABAergic inhibition in cerebellar purkinje cells in mice lacking the potassium channel Kv1. 1. J Neurosci 19:2852-64 [PubMed]
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