Citation Relationships

Legends: Link to a Model Reference cited by multiple papers

Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD (2019) Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties Neuron

   DRG neuron models investigate how ion channel levels regulate firing properties (Zheng et al 2019)

References and models cited by this paper

References and models that cite this paper

Bocksteins E, Snyders DJ (2012) Electrically silent Kv subunits: their molecular and functional characteristics. Physiology (Bethesda) 27:73-84 [Journal] [PubMed]
Carter BC, Bean BP (2009) Sodium entry during action potentials of mammalian neurons: incomplete inactivation and reduced metabolic efficiency in fast-spiking neurons. Neuron 64:898-909 [Journal] [PubMed]
Carter BC, Bean BP (2011) Incomplete inactivation and rapid recovery of voltage-dependent sodium channels during high-frequency firing in cerebellar Purkinje neurons. J Neurophysiol 105:860-71 [Journal] [PubMed]
Chang W, Kanda H, Ikeda R, Ling J, DeBerry JJ, Gu JG (2016) Merkel disc is a serotonergic synapse in the epidermis for transmitting tactile signals in mammals. Proc Natl Acad Sci U S A 113:E5491-500 [Journal] [PubMed]
Chawla K, Tripathi S, Thommesen L, Lægreid A, Kuiper M (2013) TFcheckpoint: a curated compendium of specific DNA-binding RNA polymerase II transcription factors. Bioinformatics 29:2519-20 [Journal] [PubMed]
Chi XX, Nicol GD (2007) Manipulation of the potassium channel Kv1.1 and its effect on neuronal excitability in rat sensory neurons. J Neurophysiol 98:2683-92 [Journal] [PubMed]
Delmas P, Hao J, Rodat-Despoix L (2011) Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci 12:139-53 [Journal] [PubMed]
Dib-Hajj SD, Cummins TR, Black JA, Waxman SG (2010) Sodium channels in normal and pathological pain. Annu Rev Neurosci 33:325-47 [Journal] [PubMed]
Du X, Gamper N (2013) Potassium channels in peripheral pain pathways: expression, function and therapeutic potential. Curr Neuropharmacol 11:621-40 [Journal] [PubMed]
Du X, Hao H, Gigout S, Huang D, Yang Y, Li L, Wang C, Sundt D, Jaffe DB, Zhang H, Gamper N (2014) Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission. Pain 155:2306-22 [Journal] [PubMed]
Dubin AE, Patapoutian A (2010) Nociceptors: the sensors of the pain pathway. J Clin Invest 120:3760-72 [Journal] [PubMed]
Everill B, Rizzo MA, Kocsis JD (1998) Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying proportions. J Neurophysiol 79:1814-24 [Journal] [PubMed]
Fleming MS, Luo W (2013) The anatomy, function, and development of mammalian Aß low-threshold mechanoreceptors. Front Biol (Beijing) [Journal] [PubMed]
Földy C, Darmanis S, Aoto J, Malenka RC, Quake SR, Südhof TC (2016) Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons. Proc Natl Acad Sci U S A 113:E5222-31 [Journal] [PubMed]
François A, Schüetter N, Laffray S, Sanguesa J, Pizzoccaro A, Dubel S, Mantilleri A, Nargeot J, Noël J, Wood JN, Moqrich A, Pongs O, Bourinet E (2015) The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function. Cell Rep 10:370-382 [Journal] [PubMed]
Gemes G, Koopmeiners A, Rigaud M, Lirk P, Sapunar D, Bangaru ML, Vilceanu D, Garrison SR, Ljubkovic M, Mueller SJ, Stucky CL, Hogan QH (2013) Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C-type units after painful nerve injury. J Physiol 591:1111-31 [Journal] [PubMed]
Glazebrook PA, Ramirez AN, Schild JH, Shieh CC, Doan T, Wible BA, Kunze DL (2002) Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons. J Physiol 541:467-82 [PubMed]
Gold MS, Shuster MJ, Levine JD (1996) Characterization of six voltage-gated K+ currents in adult rat sensory neurons. J Neurophysiol 75:2629-46 [Journal] [PubMed]
Gorokhova S, Gaillard S, Urien L, Malapert P, Legha W, Baronian G, Desvignes JP, Alonso S, Moqrich A (2014) Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. PLoS Genet 10:e1004081 [Journal] [PubMed]
Grigg P (1986) Biophysical studies of mechanoreceptors. J Appl Physiol (1985) 60:1107-15 [Journal] [PubMed]
Gu Z, Eils R, Schlesner M (2016) Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics 32:2847-9 [Journal] [PubMed]
Guan D, Lee JC, Tkatch T, Surmeier DJ, Armstrong WE, Foehring RC (2006) Expression and biophysical properties of Kv1 channels in supragranular neocortical pyramidal neurones. J Physiol 571:371-89 [Journal] [PubMed]
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57:473-508 [Journal] [PubMed]
Hao J, Delmas P (2011) Recording of mechanosensitive currents using piezoelectrically driven mechanostimulator. Nat Protoc 6:979-90 [Journal] [PubMed]
Harper AA, Lawson SN (1985) Electrical properties of rat dorsal root ganglion neurones with different peripheral nerve conduction velocities. J Physiol 359:47-63 [Journal] [PubMed]
Harvey AL, Robertson B (2004) Dendrotoxins: structure-activity relationships and effects on potassium ion channels. Curr Med Chem 11:3065-72 [PubMed]
Heidenreich M, Lechner SG, Vardanyan V, Wetzel C, Cremers CW, De Leenheer EM, Aránguez G, Moreno-Pelayo MÁ, Jentsch TJ, Lewin GR (2011) KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. Nat Neurosci 15:138-45 [Journal] [PubMed]
Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]
Hines ML, Carnevale NT (2000) Expanding NEURON's repertoire of mechanisms with NMODL. Neural Comput 12:995-1007 [Journal] [PubMed]
Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S (2005) A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol 3:e159 [Journal] [PubMed]
Ikeda R, Cha M, Ling J, Jia Z, Coyle D, Gu JG (2014) Merkel cells transduce and encode tactile stimuli to drive Aß-afferent impulses. Cell 157:664-75 [Journal] [PubMed]
Jackson AC, Bean BP (2007) State-dependent enhancement of subthreshold A-type potassium current by 4-aminopyridine in tuberomammillary nucleus neurons. J Neurosci 27:10785-96 [Journal] [PubMed]
Jain S, Golden JP, Wozniak D, Pehek E, Johnson EM, Milbrandt J (2006) RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. J Neurosci 26:11230-8 [Journal] [PubMed]
Julius D (2013) TRP channels and pain. Annu Rev Cell Dev Biol 29:355-84 [Journal] [PubMed]
Korngreen A, Sakmann B (2000) Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients. J Physiol 525 Pt 3:621-39 [PubMed]
   Pyramidal Neuron Deep: K+ kinetics (Korngreen, Sakmann 2000) [Model]
Li CL, Li KC, Wu D, Chen Y, Luo H, Zhao JR, Wang SS, Sun MM, Lu YJ, Zhong YQ, Hu XY, Hou R, Zhou BB, Bao L, Xiao HS, Zhang X (2016) Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Res 26:83-102 [Journal] [PubMed]
Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, Koerber HR, Woodbury CJ, Ginty DD (2011) The functional organization of cutaneous low-threshold mechanosensory neurons. Cell 147:1615-27 [Journal] [PubMed]
Lien CC, Jonas P (2003) Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J Neurosci 23:2058-68 [PubMed]
Liu PW, Bean BP (2014) Kv2 channel regulation of action potential repolarization and firing patterns in superior cervical ganglion neurons and hippocampal CA1 pyramidal neurons. J Neurosci 34:4991-5002 [Journal] [PubMed]
Liu PW, Blair NT, Bean BP (2017) Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current. J Neurosci 37:9705-9714 [Journal] [PubMed]
Löken LS, Wessberg J, Morrison I, McGlone F, Olausson H (2009) Coding of pleasant touch by unmyelinated afferents in humans. Nat Neurosci 12:547-8 [Journal] [PubMed]
Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550 [Journal] [PubMed]
Lu R, Flauaus C, Kennel L, Petersen J, Drees O, Kallenborn-Gerhardt W, Ruth P, Lukowski R, Schmidtko A (2017) KCa3.1 channels modulate the processing of noxious chemical stimuli in mice. Neuropharmacology 125:386-395 [Journal] [PubMed]
Maffie JK, Dvoretskova E, Bougis PE, Martin-Eauclaire MF, Rudy B (2013) Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. J Physiol 591:2419-27 [Journal] [PubMed]
Maksimovic S, Baba Y, Lumpkin EA (2013) Neurotransmitters and synaptic components in the Merkel cell-neurite complex, a gentle-touch receptor. Ann N Y Acad Sci 1279:13-21 [Journal] [PubMed]
Maksimovic S, Nakatani M, Baba Y, Nelson AM, Marshall KL, Wellnitz SA, Firozi P, Woo SH, Ranade S, Patapoutian A, Lumpkin EA (2014) Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature 509:617-21 [Journal] [PubMed]
Marmigère F, Ernfors P (2007) Specification and connectivity of neuronal subtypes in the sensory lineage. Nat Rev Neurosci 8:114-27 [Journal] [PubMed]
Martina M, Metz AE, Bean BP (2007) Voltage-dependent potassium currents during fast spikes of rat cerebellar Purkinje neurons: inhibition by BDS-I toxin. J Neurophysiol 97:563-71 [Journal] [PubMed]
Matsuyoshi H, Takimoto K, Yunoki T, Erickson VL, Tyagi P, Hirao Y, Wanaka A, Yoshimura N (2012) Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons. Life Sci 91:258-63 [Journal] [PubMed]
McCarter GC, Reichling DB, Levine JD (1999) Mechanical transduction by rat dorsal root ganglion neurons in vitro. Neurosci Lett 273:179-82 [PubMed]
Molineux ML, Fernandez FR, Mehaffey WH, Turner RW (2005) A-type and T-type currents interact to produce a novel spike latency-voltage relationship in cerebellar stellate cells. J Neurosci 25:10863-73 [Journal] [PubMed]
   IA and IT interact to set first spike latency (Molineux et al 2005) [Model]
Muqeem T, Ghosh B, Pinto V, Lepore AC, Covarrubias M (2018) Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn. J Neurosci 38:3729-3740 [Journal] [PubMed]
Pathak D, Guan D, Foehring RC (2016) Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex. J Neurophysiol 115:2317-29 [Journal] [PubMed]
Patil MJ, Hovhannisyan AH, Akopian AN (2018) Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines. PLoS One 13:e0198601 [Journal] [PubMed]
Paul A, Crow M, Raudales R, He M, Gillis J, Huang ZJ (2017) Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell 171:522-539.e20 [Journal] [PubMed]
Petruska JC, Napaporn J, Johnson RD, Gu JG, Cooper BY (2000) Subclassified acutely dissociated cells of rat DRG: histochemistry and patterns of capsaicin-, proton-, and ATP-activated currents. J Neurophysiol 84:2365-79 [Journal] [PubMed]
Ranade SS, Syeda R, Patapoutian A (2015) Mechanically Activated Ion Channels. Neuron 87:1162-1179 [Journal] [PubMed]
Rau KK, Petruska JC, Cooper BY, Johnson RD (2014) Distinct subclassification of DRG neurons innervating the distal colon and glans penis/distal urethra based on the electrophysiological current signature. J Neurophysiol 112:1392-408 [Journal] [PubMed]
Rhodes TH, Lossin C, Vanoye CG, Wang DW, George AL (2004) Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. Proc Natl Acad Sci U S A 101:11147-52 [Journal] [PubMed]
Ritter DM, Ho C, O'Leary ME, Covarrubias M (2012) Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons. J Physiol 590:145-61 [Journal] [PubMed]
Ritter DM, Zemel BM, Hala TJ, O'Leary ME, Lepore AC, Covarrubias M (2015) Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury. J Neurosci 35:1260-73 [Journal] [PubMed]
Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. J Neurophysiol 100:2361-80 [Journal] [PubMed]
   Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008) [Model]
Rudomin P (1999) Presynaptic selection of afferent inflow in the spinal cord. J Physiol Paris 93:329-47 [PubMed]
Rutlin M, Ho CY, Abraira VE, Cassidy C, Bai L, Woodbury CJ, Ginty DD (2014) The cellular and molecular basis of direction selectivity of Ad-LTMRs. Cell 159:1640-51 [Journal] [PubMed]
Sando R, Baumgaertel K, Pieraut S, Torabi-Rander N, Wandless TJ, Mayford M, Maximov A (2013) Inducible control of gene expression with destabilized Cre. Nat Methods 10:1085-8 [Journal] [PubMed]
Schwarz JR, Eikhof G (1987) Na currents and action potentials in rat myelinated nerve fibres at 20 and 37 degrees C. Pflugers Arch 409:569-77 [PubMed]
Shibata R, Nakahira K, Shibasaki K, Wakazono Y, Imoto K, Ikenaka K (2000) A-type K+ current mediated by the Kv4 channel regulates the generation of action potential in developing cerebellar granule cells. J Neurosci 20:4145-55 [PubMed]
Südhof TC (2012) The presynaptic active zone. Neuron 75:11-25 [Journal] [PubMed]
Sundt D, Gamper N, Jaffe DB (2015) Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study. J Neurophysiol 114:3140-53 [Journal] [PubMed]
   A model of the T-junction of a C-fiber sensory neuron (Sundt et al. 2015) [Model]
Trimmer JS (2015) Subcellular localization of K+ channels in mammalian brain neurons: remarkable precision in the midst of extraordinary complexity. Neuron 85:238-56 [Journal] [PubMed]
Tsantoulas C, McMahon SB (2014) Opening paths to novel analgesics: the role of potassium channels in chronic pain. Trends Neurosci 37:146-58 [Journal] [PubMed]
Usoskin D, Furlan A, Islam S, Abdo H, Lönnerberg P, Lou D, Hjerling-Leffler J, Haeggström J, Kharchenko O, Kharchenko PV, Linnarsson S, Ernfors P (2015) Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci 18:145-53 [Journal] [PubMed]
Vacher H, Mohapatra DP, Trimmer JS (2008) Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev 88:1407-47 [Journal] [PubMed]
Vydyanathan A, Wu ZZ, Chen SR, Pan HL (2005) A-type voltage-gated K+ currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons. J Neurophysiol 93:3401-9 [Journal] [PubMed]
Wang R, Lewin GR (2011) The Cav3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors. J Physiol 589:2229-43 [Journal] [PubMed]
Waxman SG, Zamponi GW (2014) Regulating excitability of peripheral afferents: emerging ion channel targets. Nat Neurosci 17:153-63 [Journal] [PubMed]
Wellnitz SA, Lesniak DR, Gerling GJ, Lumpkin EA (2010) The regularity of sustained firing reveals two populations of slowly adapting touch receptors in mouse hairy skin. J Neurophysiol 103:3378-88 [Journal] [PubMed]
Willis WD,Coggeshall RE (2004) Sensory Mechanisms of the Spinal Cord: Ascending Sensory Tracts and Their Descending Control :2675-2690
Woolf CJ, Ma Q (2007) Nociceptors--noxious stimulus detectors. Neuron 55:353-64 [Journal] [PubMed]
Zhang XL, Mok LP, Katz EJ, Gold MS (2010) BKCa currents are enriched in a subpopulation of adult rat cutaneous nociceptive dorsal root ganglion neurons. Eur J Neurosci 31:450-62 [Journal] [PubMed]
Zimmerman A, Bai L, Ginty DD (2014) The gentle touch receptors of mammalian skin. Science 346:950-4 [Journal] [PubMed]
Zimmerman AL, Kovatsis EM, Pozsgai RY, Tasnim A, Zhang Q, Ginty DD (2019) Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior. Neuron 102:420-434.e8 [Journal] [PubMed]
Zylka MJ, Rice FL, Anderson DJ (2005) Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 45:17-25 [Journal] [PubMed]
(88 refs)