Citation Relationships

Legends: Link to a Model Reference cited by multiple papers


Clancy CE, Kass RS (2004) Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophys J 86:2606-14 [PubMed]

   Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004)

References and models cited by this paper

References and models that cite this paper

Alekov A, Rahman MM, Mitrovic N, Lehmann-Horn F, Lerche H (2000) A sodium channel mutation causing epilepsy in man exhibits subtle defects in fast inactivation and activation in vitro. J Physiol 529 Pt 3:533-9 [PubMed]
Alekov AK, Rahman MM, Mitrovic N, Lehmann-Horn F, Lerche H (2001) Enhanced inactivation and acceleration of activation of the sodium channel associated with epilepsy in man. Eur J Neurosci 13:2171-6 [PubMed]
Azouz R, Jensen MS, Yaari Y (1996) Ionic basis of spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells. J Physiol 492 ( Pt 1):211-23 [PubMed]
Balser JR (1999) Sodium "channelopathies" and sudden death: must you be so sensitive? Circ Res 85:872-4 [PubMed]
Baulac S, Huberfeld G, Gourfinkel-An I, Mitropoulou G, Beranger A, Prud'homme JF, Baulac M, Brice A, Bruzzone R, LeGuern E (2001) First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nat Genet 28:46-8 [Journal] [PubMed]
Beeler GW, Reuter H (1977) Reconstruction of the action potential of ventricular myocardial fibres. J Physiol 268:177-210 [Journal] [PubMed]
   Mammalian Ventricular Cell (Beeler and Reuter 1977) [Model]
Bennett PB, Yazawa K, Makita N, George AL (1995) Molecular mechanism for an inherited cardiac arrhythmia. Nature 376:683-5 [Journal] [PubMed]
Brumberg JC, Nowak LG, McCormick DA (2000) Ionic mechanisms underlying repetitive high-frequency burst firing in supragranular cortical neurons. J Neurosci 20:4829-43 [PubMed]
Catterall WA (2000) From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26:13-25 [PubMed]
Clancy CE, Rudy Y (1999) Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature 400:566-9 [Journal] [PubMed]
   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
Clancy CE, Rudy Y (2002) Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation 105:1208-13 [PubMed]
   Markovian model for cardiac sodium channel (Clancy, Rudy 2002) [Model]
Clancy CE, Tateyama M, Kass RS (2002) Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. J Clin Invest 110:1251-62 [Journal] [PubMed]
Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS (2003) Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation 107:2233-7 [Journal] [PubMed]
Colbert CM, Johnston D (1998) Protein kinase C activation decreases activity-dependent attenuation of dendritic Na+ current in hippocampal CA1 pyramidal neurons. J Neurophysiol 79:491-5 [Journal] [PubMed]
Cossette P, Loukas A, Lafrenière RG, Rochefort D, Harvey-Girard E, Ragsdale DS, Dunn RJ, Rouleau GA (2003) Functional characterization of the D188V mutation in neuronal voltage-gated sodium channel causing generalized epilepsy with febrile seizures plus (GEFS). Epilepsy Res 53:107-17 [PubMed]
Escayg A, Heils A, MacDonald BT, Haug K, Sander T, Meisler MH (2001) A novel SCN1A mutation associated with generalized epilepsy with febrile seizures plus--and prevalence of variants in patients with epilepsy. Am J Hum Genet 68:866-73 [Journal] [PubMed]
Escayg A, MacDonald BT, Meisler MH, Baulac S, Huberfeld G, An-Gourfinkel I, Brice A, LeGuern E, Moulard B, Chaigne D, Buresi C, Malafosse A (2000) Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2. Nat Genet 24:343-5 [Journal] [PubMed]
Geffeney S, Brodie ED, Ruben PC, Brodie ED (2002) Mechanisms of adaptation in a predator-prey arms race: TTX-resistant sodium channels. Science 297:1336-9 [Journal] [PubMed]
Goldin AL (2001) Resurgence of sodium channel research. Annu Rev Physiol 63:871-94 [Journal] [PubMed]
Hayward LJ, Brown RH, Cannon SC (1996) Inactivation defects caused by myotonia-associated mutations in the sodium channel III-IV linker. J Gen Physiol 107:559-76 [PubMed]
Hayward LJ, Brown RH, Cannon SC (1997) Slow inactivation differs among mutant Na channels associated with myotonia and periodic paralysis. Biophys J 72:1204-19 [Journal] [PubMed]
Hayward LJ, Kim JS, Jang G, Wu FF, Asada C, Cros DP, Hoffman EP, Cannon SC, Brown RH (2001) A Na channel mutation associated with hyperkalemic periodic paralysis causes myotonia, K-induced weakness, and myopathy in mouse skeletal muscle. Neurology 56:A81
Hayward LJ, Sandoval GM, Cannon SC (1999) Defective slow inactivation of sodium channels contributes to familial periodic paralysis. Neurology 52:1447-53 [PubMed]
Horn R, Vandenberg CA (1984) Statistical properties of single sodium channels. J Gen Physiol 84:505-34 [PubMed]
Jentsch TJ (2000) Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 1:21-30 [Journal] [PubMed]
Jurkat-Rott K, Mitrovic N, Hang C, Kouzmekine A, Iaizzo P, Herzog J, Lerche H, Nicole S, Vale-Santos J, Chauveau D, Fontaine B, Lehmann-Horn F (2000) Voltage-sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current. Proc Natl Acad Sci U S A 97:9549-54 [PubMed]
Kearney JA, Plummer NW, Smith MR, Kapur J, Cummins TR, Waxman SG, Goldin AL, Meisler MH (2001) A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities. Neuroscience 102:307-17 [PubMed]
Kidd FL, Isaac JT (1999) Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses. Nature 400:569-73 [Journal] [PubMed]
Lerche H, Jurkat-Rott K, Lehmann-Horn F (2001) Ion channels and epilepsy. Am J Med Genet 106:146-59 [Journal] [PubMed]
Lerche H, Weber YG, Baier H, Jurkat-Rott K, Kraus de Camargo O, Ludolph AC, Bode H, Lehmann-Horn F (2001) Generalized epilepsy with febrile seizures plus: further heterogeneity in a large family. Neurology 57:1191-8 [PubMed]
Lossin C, Rhodes TH, Desai RR, Vanoye CG, Wang D, Carniciu S, Devinsky O, George AL (2003) Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. J Neurosci 23:11289-95 [PubMed]
Lossin C, Wang DW, Rhodes TH, Vanoye CG, George AL (2002) Molecular basis of an inherited epilepsy. Neuron 34:877-84 [PubMed]
Luo CH, Rudy Y (1991) A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circ Res 68:1501-26 [PubMed]
   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
   Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]
Luo CH, Rudy Y (1994) A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 74:1071-96 [PubMed]
   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
Macdonald BT, Escayg A, Spampanato J, Montalenti E, Benna P, Goldin AL, Meisler MH (2001) A novel mutation of the sodium channel SCN1A in the epilepsy syndrome GEFS plus. Am J Hum Genet 69:600
Maier SK, Westenbroek RE, Schenkman KA, Feigl EO, Scheuer T, Catterall WA (2002) An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A 99:4073-8 [Journal] [PubMed]
McPhee JC, Ragsdale DS, Scheuer T, Catterall WA (1995) A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation. J Biol Chem 270:12025-34 [PubMed]
Meisler MH, Kearney J, Escayg A, MacDonald BT, Sprunger LK (2001) Sodium channels and neurological disease: insights from Scn8a mutations in the mouse. Neuroscientist 7:136-45 [Journal] [PubMed]
Members of the Sicilian Gambit (2001) New approaches to antiarrhythmic therapy, Part I: emerging therapeutic applications of the cell biology of cardiac arrhythmias. Circulation 104:2865-73 [PubMed]
Migliore M, Cook EP, Jaffe DB, Turner DA, Johnston D (1995) Computer simulations of morphologically reconstructed CA3 hippocampal neurons. J Neurophysiol 73:1157-68 [Journal] [PubMed]
   CA3 Pyramidal Neuron (Migliore et al 1995) [Model]
Noble D (2002) The rise of computational biology. Nat Rev Mol Cell Biol 3:459-63 [Journal] [PubMed]
Noble D (2002) Unraveling the genetics and mechanisms of cardiac arrhythmia. Proc Natl Acad Sci U S A 99:5755-6 [Journal] [PubMed]
Spampanato J, Escayg A, Meisler MH, Goldin AL (2001) Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2. J Neurosci 21:7481-90 [PubMed]
Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT (2002) Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science 297:1333-6 [Journal] [PubMed]
Steinlein OK (2001) Genes and mutations in idiopathic epilepsy. Am J Med Genet 106:139-45 [Journal] [PubMed]
Traub RD, Jefferys JG, Miles R, Whittington MA, Tóth K (1994) A branching dendritic model of a rodent CA3 pyramidal neurone. J Physiol 481 ( Pt 1):79-95 [PubMed]
Traub RD, Wong RK, Miles R, Michelson H (1991) A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. J Neurophysiol 66:635-50 [Journal] [PubMed]
Vandenberg CA, Horn R (1984) Inactivation viewed through single sodium channels. J Gen Physiol 84:535-64 [PubMed]
Vorgerd M, Bolz H, Patzold T, Kubisch C, Malin JP, Mortier W (1999) Phenotypic variability in rippling muscle disease. Neurology 52:1453-9 [PubMed]
Wehrens XH, Abriel H, Cabo C, Benhorin J, Kass RS (2000) Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis. Circulation 102:584-90 [PubMed]
Weiss LA, Escayg A, Kearney JA, Trudeau M, MacDonald BT, Mori M, Reichert J, Buxbaum JD, Meisler MH (2003) Sodium channels SCN1A, SCN2A and SCN3A in familial autism. Mol Psychiatry 8:186-94 [Journal] [PubMed]
Westenbroek RE, Merrick DK, Catterall WA (1989) Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons. Neuron 3:695-704 [PubMed]
Gurkiewicz M, Korngreen A, Waxman SG, Lampert A (2011) Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. J Neurophysiol 105:1546-57 [Journal] [PubMed]
   HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011) [Model]
Kahlig KM, Misra SN, George AL (2006) Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. J Neurosci 26:10958-66 [Journal] [PubMed]
Xu J, Clancy CE (2008) Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study. PLoS One 3:e2056 [Journal] [PubMed]
   Ionic mechanisms of bursting in CA3 pyramidal neurons (Xu and Clancy 2008) [Model]
(57 refs)