Modulation of septo-hippocampal theta activity by GABAA receptors (Hajos et al. 2004)

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Accession:116567
Theta frequency oscillation of the septo-hippocampal system has been considered as a prominent activity associated with cognitive function and affective processes. ... In the present experiments we applied a combination of computational and physiological techniques to explore the functional role of GABAA receptors in theta oscillation. ... In parallel to these experimental observations, a computational model has been constructed by implementing a septal GABA neuron model with a CA1 hippocampal model containing three types of neurons (including oriens and basket interneurons and pyramidal cells; latter modeled by multicompartmental techniques; for detailed model description with network parameters see online addendum: http://geza.kzoo.edu/theta). This connectivity made the network capable of simulating the responses of the septo-hippocampal circuitry to the modulation of GABAA transmission, and the presently described computational model proved suitable to reveal several aspects of pharmacological modulation of GABAA receptors. In addition, computational findings indicated different roles of distinctively located GABAA receptors in theta generation.
Reference:
1 . Hajos M, Hoffmann WE, Orban G, Kiss T, Erdi P (2004) Modulation of septo-hippocampal Theta activity by GABAA receptors: an experimental and computational approach. Neuroscience 126:599-610 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA1 interneuron oriens alveus cell; Hippocampus CA1 basket cell;
Channel(s): I Na,t; I A; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; Hippocampus CA1 interneuron oriens alveus cell; GabaA; I Na,t; I A; I K; I M; I h; I K,Ca; I Calcium;
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HajosEtAl2004
theta_download
weblink
readme.txt
suppl_mat.pdf
                            
This is the readme for the models associated with the paper:

Hajos M, Hoffmann WE, Orban G, Kiss T, Erdi P (2004) Modulation of
septo-hippocampal Theta activity by GABAA receptors: an experimental
and computational approach. Neuroscience 126:599-610

These models were previously available as a web link to a model as
shown in the weblink folder; the .g and .p files in this archive were
from a file called theta.tgz which when expanded created the
theta_download folder available in this archive.

The papers complete supplementary material is also available in this
archive (see suppl_mat.pdf).