"Synfire chains have long been suggested as a substrate for perception and information processing in the nervous system.
However, embedding activation chains in a densely connected nervous matrix risks spread of signal that will obscure or obliterate the message.
We used computer modeling and physiological measurements in rat hippocampus to assess this problem of activity broadening.
We simulated a series of neural modules with feedforward propagation and random connectivity within each module and from one module to the next. ..."
Lytton WW, Orman R, Stewart M (2008) Broadening of activity with flow across neural structures. Perception 37:401-7 [PubMed]