A Web-based simulation system of the spinal
cord circuitry responsible for muscle control is described.
The simulator employs two-compartment motoneuron
models for S, FR and FF types, with synaptic inputs acting
through conductance variations.
Four motoneuron pools
with their associated interneurons are represented in the
simulator, with the possibility of inclusion of more than
2,000 neurons and 2,000,000 synapses.
Inputs to the motoneuron pool come from populations of
interneurons (Ia reciprocal inhibitory interneurons, Ib
interneurons, and Renshaw cells) and from stochastic point
processes associated with descending tracts.
The generation of the H-reflex
by the Ia-motoneuron pool system and its modulation
by spinal cord interneurons is included in the simulation
Cisi RR, Kohn AF (2008) Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture. J Comput Neurosci 25:520-42 [PubMed]