Contribution of ATP-sensitive potassium channels in the neuronal network (Huang et al. 2009)

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Accession:120243
Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. ... We also used a simulation model to evaluate intracellular adenosine triphosphate (ATP) and neuroexcitability. ... In the simulation, increased intracellular ATP concentration promoted action potential firing. This finding that rats with DH had more brain damage after SE than rats without diabetes suggests the importance of intensively treating hyperglycemia and seizures in diabetic patients with epilepsy.
Reference:
1 . Huang CW, Cheng JT, Tsai JJ, Wu SN, Huang CC (2009) Diabetic Hyperglycemia Aggravates Seizures and Status Epilepticus-induced Hippocampal Damage. Neurotox Res 15:71-81 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Hodgkin-Huxley neuron;
Channel(s): ATP-senstive potassium current;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Action Potentials; Epilepsy;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
Search NeuronDB for information about:  ATP-senstive potassium current;
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