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Computer model of clonazepam's effect in thalamic slice (Lytton 1997)
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Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice.
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Thalamus geniculate nucleus/lateral principal GLU cell;
Thalamus reticular nucleus GABA cell;
I T low threshold;
Lytton, William [bill.lytton at downstate.edu];
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Thalamus geniculate nucleus/lateral principal GLU cell
Thalamus reticular nucleus GABA cell
I T low threshold
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