A model of the temporal pattern generator of C. elegans egg-laying behavior (Zhang et. al 2010)


Help downloading and running models
Accession:127321
"... We suggest that the HSN neuron is the executive neuron driving egg-laying events. We propose that the VC neurons act as "single egg counters" that inhibit HSN activity for short periods in response to individual egg-laying events. We further propose that the uv1 neuroendocrine cells are "cluster counters", which inhibit HSN activity for longer periods and are responsible for the time constant of the inactive phase. Together they form an integrated circuit that drives the clustered egg-laying pattern. ..."
Reference:
1 . Zhang M, Schafer WR, Breitling R (2010) A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior. BMC Syst Biol 4:81 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Egg-laying circuit;
Cell Type(s): C elegans Hermaphrodite-Specific neuron (HSN); C elegans VC motor neuron; C elegans uterine-vulval cell (uv1);
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: R (web link to model);
Model Concept(s): Temporal Pattern Generation; Simplified Models;
Implementer(s): Breitling, Rainer; Zhang, Mi [mi.zhang at gmail.com];
(located via links below)