"Neural circuits display complex activity patterns both
spontaneously and when responding to a stimulus or
generating a motor output.
How are these two forms
of activity related?
We develop a procedure called
FORCE learning for modifying synaptic strengths
either external to or within a model neural network
to change chaotic spontaneous activity into a wide
variety of desired activity patterns.
reproduce data on premovement activity in motor
and premotor cortex, and suggest that synaptic plasticity
may be a more rapid and powerful modulator of
network activity than generally appreciated."
Sussillo D, Abbott LF (2009) Generating coherent patterns of activity from chaotic neural networks. Neuron 63:544-57 [PubMed]