Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)

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Accession:139421
"Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare, OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta. ..."
Reference:
1 . Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Ketamine disrupts theta modulation of gamma in a computer model of hippocampus Journal of Neuroscience 31(32):11733-11743 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal cell; Hippocampus CA3 interneuron basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s): I L high threshold; I A; I K; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; NMDA; Glutamate;
Gene(s): HCN1; HCN2;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Oscillations; Synchronization; Therapeutics; Pathophysiology; Schizophrenia; Information transfer; Brain Rhythms;
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Neymotin, Sam [samn at neurosim.downstate.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; Hippocampus CA3 interneuron basket cell; GabaA; NMDA; Glutamate; I L high threshold; I A; I K; I K,Ca; Gaba; Glutamate;
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hpcdemo
readme.html
CA1ih.mod *
CA1ika.mod *
CA1ikdr.mod *
CA1ina.mod *
caolmw.mod *
capr.mod *
icaolmw.mod *
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kdrpyrkop.mod *
misc.mod *
MyExp2Syn.mod *
MyExp2SynAlpha.mod *
MyExp2SynBB.mod *
MyExp2SynNMDA.mod *
MyExp2SynNMDABB.mod *
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nafpyrkop.mod *
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: $Id: nafpr.mod,v 1.1 2009/11/05 15:09:12 samn Exp $ 
COMMENT

//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
//
// NOTICE OF COPYRIGHT AND OWNERSHIP OF SOFTWARE
//
// Copyright 2007, The University Of Pennsylvania
// 	School of Engineering & Applied Science.
//   All rights reserved.
//   For research use only; commercial use prohibited.
//   Distribution without permission of Maciej T. Lazarewicz not permitted.
//   mlazarew@seas.upenn.edu
//
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

ENDCOMMENT

NEURON {

	SUFFIX nafpr
	USEION na WRITE ina
	RANGE gna, ina
}
	
UNITS {

	(mA) = (milliamp)
	(mV) = (millivolt)
	(mS) = (millisiemens)
}

PARAMETER {

    gna  = 30 (mS/cm2)
    ena  = 55 (mV)
}
    
ASSIGNED {

    v    (mV)
    ina  (mA/cm2)
    minf (1)
    hinf (1)
    tauh (ms)
}

STATE { h }

INITIAL {
    
    rates(v)
    h  = hinf
}

BREAKPOINT {

	SOLVE states METHOD cnexp
	
	ina = (1e-3) * gna * minf^2 * h * (v-ena)
}


DERIVATIVE states { 

    rates(v)
    h' = (hinf-h)/tauh
}


:ina
PROCEDURE rates(v(mV)) { LOCAL a, b

    a    = fun3(v,  -46.9, -0.32,    -4) 
    b    = fun3(v,  -19.9,  0.28,     5) 
    minf = a/(a+b)
    
    a    = fun1(v,  -43,    0.128,  -18) 
    b    = fun2(v,  -20,    4,       -5)
    hinf = a/(a+b)
    tauh = 1.0/(a+b)
}

INCLUDE "aux_fun.inc"