"Abnormalities in oscillations have been suggested to play a role in schizophrenia.
We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and
without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic.
Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare,
OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells
primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta.
Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Ketamine disrupts ? modulation of ? in a computer model of hippocampus. J Neurosci 31:11733-43 [PubMed]