Engaging distinct oscillatory neocortical circuits (Vierling-Claassen et al. 2010)

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Accession:141273
"Selective optogenetic drive of fast-spiking (FS) interneurons (INs) leads to enhanced local field potential (LFP) power across the traditional “gamma” frequency band (20–80 Hz; Cardin et al., 2009). In contrast, drive to regular-spiking (RS) pyramidal cells enhances power at lower frequencies, with a peak at 8 Hz. The first result is consistent with previous computational studies emphasizing the role of FS and the time constant of GABAA synaptic inhibition in gamma rhythmicity. However, the same theoretical models do not typically predict low-frequency LFP enhancement with RS drive. To develop hypotheses as to how the same network can support these contrasting behaviors, we constructed a biophysically principled network model of primary somatosensory neocortex containing FS, RS, and low-threshold spiking (LTS) INs. ..."
Reference:
1 . Vierling-Claassen D, Cardin JA, Moore CI, Jones SR (2010) Computational modeling of distinct neocortical oscillations driven by cell-type selective optogenetic drive: separable resonant circuits controlled by low-threshold spiking and fast-spiking interneurons. Front Hum Neurosci 4:198 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L2/6 pyramidal intratelencephalic cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s): I Na,t; I T low threshold; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Detailed Neuronal Models; Brain Rhythms; Evoked LFP; Touch;
Implementer(s): Vierling-Claassen, Dorea ;
Search NeuronDB for information about:  Neocortex V1 L2/6 pyramidal intratelencephalic cell; I Na,t; I T low threshold; I K; I M; I h; I K,Ca; I Calcium;
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Vierling-ClaassenEtAl2010
batchsims
confiles
README
ar.mod
ca.mod *
cad.mod *
cat.mod
fdsexp2syn.mod *
Gfluct.mod *
gnetstim.mod
kca.mod *
km.mod *
kv.mod *
na_2.mod
light_batch_FSdrive.hoc
light_genconn_DB.m
lightgamma_drive_DB.hoc
lightgamma_init_DB.hoc
lightgamma_LFP_DB.hoc
lightgamma_localconn_DB.hoc
lightgamma_network_DB.hoc
lightgamma_noise_DB.hoc
lightgamma_wiring_DB.hoc
lightgamma_wiring_proc_DB.hoc
                            
// Dorea Vierling-Claassen 2010
// Call all relevant processes and run sim for 600ms, note that simulations for paper were 15100 
// ms and then averaged over fifteen 1 second blocks
// (the first 100 ms were disregarded, see Vierling-Claassen et al., 2010 for further info on 
// processing)

tstop=600
//tstop=15100

// Sets dimensions of grid in which cells are placed 
// (in this case, 6X6, for a total of 36 pyramidal cells)

X_DIM = 6
Y_DIM = 6

// center of spatial decay for for drive 
FSx=2 
FSy=2

load_file("nrngui.hoc")

// This file defines cell morphology, intrinsic currents, and synaptic dynamics
load_file("lightgamma_network_DB.hoc")

// processes for wiring between populations, depends on files controlling random connectivity 
// in confiles folder, connectivity is fixed for all runs
load_file("lightgamma_wiring_DB.hoc")

// commands for light drive
load_file("lightgamma_wiring_proc_DB.hoc")


// Intra-cortical wiring
load_file("lightgamma_localconn_DB.hoc")

// Define light drive objects
objref FB

FB = new FeedX() // Feed-Back (eg. Pre-frontal input) 
FB.pp.MeanInterval=1000/8

// connect drive to cortex (needs to come after defn of FF)
load_file("lightgamma_drive_DB.hoc")

// add background noise to cells, modification of Destexhe et al 2001 noise
load_file("lightgamma_noise_DB.hoc")

//generate average over pyramidal cell voltages
load_file("lightgamma_LFP_DB.hoc")

// important to set temperature!
forall celsius=30