MicrocircuitDB: Network model with neocortical architecture (Anderson et al 2007,2012; Azhar et al 2012)

Network model with neocortical architecture (Anderson et al 2007,2012; Azhar et al 2012)

Download zip file
Help downloading and running models

Model Information
Model File

Accession:141507

Architecturally realistic neocortical model using seven classes of excitatory and inhibitory single compartment Hodgkin-Huxley cells. This is an addendum to ModelDB Accession # 98902, Studies of stimulus parameters for seizure disruption (Anderson et al. 2007). Wiring is adapted from the minicolumn hypothesis and incorporates visual and neocortical wiring data. Simulation demonstrates spontaneous bursting onset and cessation. This activity can be induced by random fluctuations in the surrounding background input.
Reference:
1 . Anderson WS, Kudela P, Cho J, Bergey GK, Franaszczuk PJ (2007) Studies of stimulus parameters for seizure disruption using neural network simulations. Biol Cybern 97:173-94 [PubMed]
2 . Anderson WS, Kudela P, Weinberg S, Bergey GK, Franaszczuk PJ (2009) Phase-dependent stimulation effects on bursting activity in a neural network cortical simulation. Epilepsy Res 84:42-55 [PubMed]
3 . Anderson WS, Azhar F, Kudela P, Bergey GK, Franaszczuk PJ (2012) Epileptic seizures from abnormal networks: why some seizures defy predictability. Epilepsy Res 99:202-13 [PubMed]
4 . Azhar F, Anderson WS (2012) Predicting single-neuron activity in locally connected networks. Neural Comput 24:2655-77 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):	Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron;
Channel(s):	I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium;
Gap Junctions:
Receptor(s):	AMPA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment:	C or C++ program;
Model Concept(s):	Bursting; Epilepsy; Vision;
Implementer(s):

Search NeuronDB for information about: Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; AMPA; Gaba; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium;

Download the displayed file

AndersonEtAl2011

netclustwacnmdadiff.c

rnetcolumn.txt *

These are the files for a paper under review: and a fresh paper:

Anderson WS, Azhar F, Kudela P, Bergey GK, Franaszczuk PJ. Epileptic
seizures from abnormal networks: Why some seizures defy
predictability. Epi Res doi: 10.1016/j.eplepsyres.2011.11.006.