Modulation of hippocampal rhythms by electric fields and network topology (Berzhanskaya et al. 2013)

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Accession:144589
“… Here we present experimental and computational evidence of the interplay among hippocampal synaptic circuitry, neuronal morphology, external electric fields, and network activity. Electrophysiological data are used to constrain and validate an anatomically and biophysically realistic model of area CA1 containing pyramidal cells and two interneuron types: dendritic- and perisomatic-targeting. We report two lines of results: addressing the network structure capable of generating theta-modulated gamma rhythms, and demonstrating electric field effects on those rhythms. First, theta-modulated gamma rhythms require specific inhibitory connectivity. … The second major finding is that subthreshold electric fields robustly alter the balance between different rhythms. …”
Reference:
1 . Berzhanskaya J, Chernyy N, Gluckman BJ, Schiff SJ, Ascoli GA (2013) Modulation of hippocampal rhythms by subthreshold electric fields and network topology. J Comput Neurosci 34(3):369-389 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Brain Rhythms;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell;
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BerzThetaGamm2013
readme.txt
h.mod
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3.mod *
nax.mod *
xtra.mod
CurRun.ses
GraphandElf.ses
HipNetStart.hoc
interpxyz.hoc
mosinit.hoc
netwOPb.hoc
setpointers.hoc
                            
This is the readme for the model associated with the paper:

Berzhanskaya J, Chernyy N, Gluckman BJ, Schiff SJ, Ascoli GA (2013)
Modulation of hippocampal rhythms by subthreshold electric fields and
network topology. J Comput Neurosci 34(3):369-389

This is the code that the paper authors used.

This NEURON model simulates OPb network made of 20 Pyramidal, Oriens
and Basket cells (60 total).  Biophysically realistic Pyramidal cells
have full 3D morphological structure, while Oriens and Basket cells
have simplfied compartmental structure.  Synaptic weight distribution
on Pyramidal cells is modeled after Li and Ascoli (2006, 2008).
Experimental data on the external electric field effects at the single
cell level are collected using control circuits described in Gluckman
et al. (1996, 2001). External electric field application is simulated
after C. McIntyre and M. Robertson.

Usage instructions:
-------------------

Either auto-launch from ModelDB or download, extract the archive and
compile the mod files with nrnivmodl (unix/linux) or mknrndll (pc or
mac). (The file auto-launch will start is HipNetStart.hoc).  If
running by hand use "nrngui mosinit.hoc" (unix/linux) or double
clicking mosinit.hoc (mswin) or dragging and dropping the mosinit.hoc
file onto the nrngui icon (mac os x).

Once the simulation has started three actions are required to run the
network:

1. Select the network (Click the netwOPb button)
2. Set up electric field (Click the Uniform Field button)
3. Choose initial current injection (recommended 0.23-0.26 nA) (type
0.23 into the "Int Stim Amp (nA)" field in the "Internal Current
Clamp" window)

Current version runs in Neuron 7