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Distributed synaptic plasticity and spike timing (Garrido et al. 2013)
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Here we have used a computational model to simulate the impact of multiple distributed synaptic weights in the cerebellar granular layer network. In response to mossy fiber bursts, synaptic weights at multiple connections played a crucial role to regulate spike number and positioning in granule cells. Interestingly, different combinations of synaptic weights optimized either first-spike timing precision or spike number, efficiently controlling transmission and filtering properties. These results predict that distributed synaptic plasticity regulates the emission of quasi-digital spike patterns on the millisecond time scale and allows the cerebellar granular layer to flexibly control burst transmission along the mossy fiber pathway.
Garrido JA, Ros E, D'Angelo E (2013) Spike timing regulation on the millisecond scale by distributed synaptic plasticity at the cerebellum input stage: a simulation study.
Front Comput Neurosci
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Cerebellum interneuron granule cell;
Cerebellum golgi cell;
Long-term Synaptic Plasticity;
Garrido, Jesus A [jesus.garrido at unipv.it];
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Cerebellum interneuron granule cell
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