Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
# $Id: Usermake,v 1.5 2005/11/07 21:14:19 svitak Exp $
# Usermake: A Makefile template for compiling a new version of
#           GENESIS that includes user-defined objects and libraries.
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# ----------------------------------------------------------------------
# ----------------------------------------------------------------------
# SYSTEM CONFIGURATION VARIABLES ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

# The INSTALLDIR variable should refer to the GENESIS installation
# directory.  This is equivalent to the value of the variable in
# the top-level GENESIS Makefile. Note that `pwd` may not work as
# expected. Use a full path instead.

INSTALLDIR   = /usr/local/genesis
TMPDIR   = /tmp

# The following should have the same values as the settings you used for
# these same variables in the file genesis/src/Makefile.  Please consult
# that file for the values to use.

OS	  = 
XLIB      = 
CC	  = 
CPP	  = 
LD        = 
LEXLIB    = 

# USER CONFIGURATION VARIABLES ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

# Name to give your new GENESIS executable.

SIMNAME = newgenesis

# The directory containing any user library modules.
# E.g.: USERDIR = newlib1 newlib2


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# OPTIONAL GENESIS LIBRARIES ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

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OLDCONN    = $(SIMLIB)/axonlib.o \
	     $(SIMLIB)/synlib.o \
	     $(SIMLIB)/perlib.o \
	     $(SIMLIB)/simconnlib.o \
OLDCONNLIB = axon synapse personal simconn toolconn

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# KINETICSLIB to exclude the kinetics library.
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FMT1OBJ   = $(SIMLIB)/FMT1lib.o
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DISKIO    = $(SIMLIB)/diskiolib.o $(FMT1OBJ) $(NETCDFOBJ)
DISKIOLIB = diskio



# This is the graphics widget and draw library.  It is needed by just
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	   $(SIMLIB)/libDraw.a \
	   $(SIMLIB)/libWidg.a \
XODUSLIB = xo  draw  widg

# end of user-configurable section.

# ----------------------------------------------------------------------
# ----------------------------------------------------------------------


SHELL	      = /bin/sh

SIMLIB 	      = $(INSTALLDIR)/lib
SIMSRC 	      = $(INSTALLDIR)/src

BASE          = $(SIMLIB)/simlib.o \
		$(SIMLIB)/ss.o \
		$(SIMLIB)/shelllib.o \
		$(SIMLIB)/utillib.o \
		$(SIMLIB)/buflib.o \
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		$(SIMLIB)/hhlib.o \
		$(SIMLIB)/devlib.o \
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		$(OLDCONN) \
		$(SIMLIB)/newconnlib.o \
		$(DISKIO) \

GENESIS       = $(BASE) loadlib.o
NXGENESIS     = $(BASE) nxloadlib.o

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LIBLIST       = output \
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		devices \
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		user \
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default: userlibs $(SIMNAME)

	@(for i in $(USERDIR); do \
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nxloadlib.c: nxliblist
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	@(for i in $(USERDIR); do echo cd $$i; cd $$i; make clean; cd ..;done)
	@rm -f loadlib.[oc] liblist


nxgenesis $(NXSIMNAME): userlibs $(NXGENESIS) $(USEROBJ) 

# End of Usermake.