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Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
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Model Information
Model File
Accession:
154096
"... As cells die and synapses lose their drive, remaining cells suffer an initial decrease in activity. Neuronal homeostatic synaptic scaling then provides a feedback mechanism to restore activity. ... The scaling mechanism increases the firing rates of remaining cells in the network to compensate for decreases in network activity. However, this effect can itself become a pathology, ... Here, we present a mechanistic explanation of how directed brain stimulation might be expected to slow AD progression based on computational simulations in a 470-neuron biomimetic model of a neocortical column. ... "
Reference:
1 .
Rowan MS, Neymotin SA, Lytton WW (2014) Electrostimulation to reduce synaptic scaling driven progression of Alzheimer's disease.
Front Comput Neurosci
8
:39
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Neocortex V1 interneuron basket PV GABA cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiny stellate cell;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Channel(s):
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Long-term Synaptic Plasticity;
Aging/Alzheimer`s;
Deep brain stimulation;
Homeostasis;
Implementer(s):
Lytton, William [bill.lytton at downstate.edu];
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Rowan, Mark [m.s.rowan at cs.bham.ac.uk];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
Neocortex V1 interneuron basket PV GABA cell
;
GabaA
;
AMPA
;
NMDA
;
Gaba
;
Glutamate
;
Download the displayed file
/
RowanEtAl2014
batchscripts
mod
README
alz.hoc
alzinfo.m
autotune.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
basestdp.hoc
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
batch.hoc
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
batch2.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
batchcommon
checkirreg.hoc
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
clusterrun.sh
col.dot
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
col.hoc
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Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
comppowspec.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
condisconcellfig.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
condisconpowfig.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
declist.hoc
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Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
decmat.hoc
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Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
decnqs.hoc
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Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
decvec.hoc
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
default.hoc
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CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
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Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
drline.hoc
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
e2hubsdisconpow.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
e2incconpow.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
filtutils.hoc
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Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
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Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
flexinput.hoc
geom.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
graphplug.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
grvec.hoc
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infot.hoc
*
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init.hoc
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
labels.hoc
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Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
load.hoc
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
local.hoc
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Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
makepopspikenq.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
matfftpowplug.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
matpmtmplug.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
matpmtmsubpopplug.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
matspecplug.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
mosinit.hoc
network.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
nload.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
nqpplug.hoc
*
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
nqs.hoc
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nqsnet.hoc
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nrnoc.hoc
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Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
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Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
params.hoc
plot.py
plotavg.py
plotbatch.sh
plotbatchcluster.sh
plotdeletions.py
plotntes.py
powchgtest.hoc
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pyhoc.py
python.hoc
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pywrap.hoc
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ratlfp.dat
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redE2.hoc
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run.hoc
runsim.sh
setup.hoc
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shufmua.hoc
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Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
sim.hoc
simctrl.hoc
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Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
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Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
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stats.hoc
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syncode.hoc
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vsampenplug.hoc
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writedata.hoc
xgetargs.hoc
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Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
// $Id: geom.hoc,v 1.1 2008/05/21 22:38:38 samn Exp $
