Find models by
Find models for
Find models of
Bursting and oscillations in RD1 Retina driven by AII Amacrine Neuron (Choi et al. 2014)
Download zip file
Help downloading and running models
"In many forms of retinal degeneration, photoreceptors die but inner retinal circuits remain intact. In the rd1 mouse, an established model for blinding retinal diseases, spontaneous activity in the coupled network of AII amacrine and ON cone bipolar cells leads to rhythmic bursting of ganglion cells. Since such activity could impair retinal and/or cortical responses to restored photoreceptor function, understanding its nature is important for developing treatments of retinal pathologies. Here we analyzed a compartmental model of the wild-type mouse AII amacrine cell to predict that the cell's intrinsic membrane properties, specifically, interacting fast Na and slow, M-type K conductances, would allow its membrane potential to oscillate when light-evoked excitatory synaptic inputs were withdrawn following photoreceptor degeneration. ..."
Choi H, Zhang L, Cembrowski MS, Sabottke CF, Markowitz AL, Butts DA, Kath WL, Singer JH, Riecke H (2014) Intrinsic bursting of AII amacrine cells underlies oscillations in the rd1 mouse retina.
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
for information about:
File not selected
<- Select file from this column.