Hierarchical network model of perceptual decision making (Wimmer et al 2015)

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Accession:168867
Neuronal variability in sensory cortex predicts perceptual decisions. To investigate the interaction of bottom-up and top-down mechanisms during the decision process, we developed a hierarchical network model. The network consists of two circuits composed of leaky integrate-and-fire neurons: an integration circuit (e.g. LIP, FEF) and a sensory circuit (MT), recurrently coupled via bottom-up feedforward connections and top-down feedback connections. The integration circuit accumulates sensory evidence and produces a binary categorization due to winner-take-all competition between two decision-encoding populations (X.J. Wang, Neuron, 2002). The sensory circuit is a balanced randomly connected EI-network, that contains neural populations selective to opposite directions of motion. We have used this model to simulate a standard two-alternative forced-choice motion discrimination task.
Reference:
1 . Wimmer K, Compte A, Roxin A, Peixoto D, Renart A, de la Rocha J (2015) Sensory integration dynamics in a hierarchical network explains choice probabilities in cortical area MT. Nat Commun 6:6177 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Abstract integrate-and-fire leaky neuron;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: Brian; Python;
Model Concept(s): Attractor Neural Network; Winner-take-all;
Implementer(s): Wimmer, Klaus [wimmer.klaus at gmail.com];
Search NeuronDB for information about:  AMPA; NMDA; Gaba;