Model of eupnea and sigh generation in respiratory network (Toporikova et al 2015)

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Accession:181962
Based on recent in vitro data obtained in the mouse embryo, we have built a computational model consisting of two compartments, interconnected through appropriate synapses. One compartment generates sighs and the other produces eupneic bursts. The model reproduces basic features of simultaneous sigh and eupnea generation (two types of bursts differing in terms of shape, amplitude, and frequency of occurrence) and mimics the effect of blocking glycinergic synapses
Reference:
1 . Toporikova N, Chevalier M, Thoby-Brisson M (2015) Sigh and eupnea rhythmogenesis involves distinct interconnected subpopulations: a combined computational and experimental study eNeuro 2(2):1-18 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,p; I K,leak; I h; I CAN; I Calcium; Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: Python;
Model Concept(s): Calcium dynamics;
Implementer(s):
Search NeuronDB for information about:  I Na,p; I K,leak; I h; I CAN; I Calcium; Ca pump;
 
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