Olfactory Bulb mitral-granule network generates beta oscillations (Osinski & Kay 2016)

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Accession:185464
This model of the dendrodendritic mitral-granule synaptic network generates gamma and beta oscillations as a function of the granule cell excitability, which is represented by the granule cell resting membrane potential.
Reference:
1 . Osinski BL, Kay LM (2016) Granule cell excitability regulates gamma and beta oscillations in a model of the olfactory bulb dendrodendritic microcircuit. J Neurophysiol 116:522-39 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Dendrite;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; Abstract integrate-and-fire leaky neuron;
Channel(s): I N; I Sodium; I Calcium;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: MATLAB;
Model Concept(s): Oscillations; Active Dendrites; Extracellular Fields; Calcium dynamics; Gamma oscillations; Beta oscillations; Olfaction;
Implementer(s): Osinski, Boleslaw [boleszek at uchicago.edu];
Search NeuronDB for information about:  Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; AMPA; NMDA; Gaba; I N; I Sodium; I Calcium; Gaba; Glutamate;
Path Kay/GCExcitability
dt 0.1
tsim 700
tinit 0.1
tfinal 700
Inoise 0.005
Wmin 0.0134
Respiration false
RespFreq 5
SpikeV 65e-3


nmitral 45
ngradist 720
ngraprox 1
NoiseMit 0.001
NoiseGradist 0.001
NoiseGraprox 0.001
hCaflag true
rhoCa 100
ExFrac 1
DistalON true
ProximalON false
GraGracon false
CChanceGraMit 0.3
CChanceGraGra 0


NEURONS


Mitral
tau 5
tauAMPA1 1
tauAMPA2 2
tauGABA1 0.5
tauGABA2 5
EAMPA 0e-3
EGABA -75e-3
gmaxAMPA 15e-3
gmaxGABA 1
Vrest -70e-3
Vhyper -80e-3
FThresh -63e-3
wGABAGR 0.0165

GraDistal
tau 5
tauAMPA1 0.5
tauAMPA2 1
tauNMDA1 2
tauNMDA2 75
tauVDCC 18
EAMPA 0e-3
ECa 100e-3
gmaxAMPA 0
Vrest -0.060
Vhyper -80e-3
CCaTh 1.5
wAMPAMI 0.03
wNMDAMI 0.04
wVDCCMI 2400

GraProximal
tau 5
tauPROX1 1
tauPROX2 2
tauGABA1 1
tauGABA2 2
EAMPA 0e-3
EGABA -75e-3
gmaxAMPA 0
gmaxGABA 30e-3
Vrest -70e-3
Vhyper -80e-3
FThresh -60e-3
wGABAGR 0.6


end