Functional properties of dendritic gap junctions in Cerebellar Golgi cells (Szoboszlay et al. 2016)

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Accession:189186
" ... We investigated the properties of gap junctions in cerebellar interneurons by combining paired somato-somatic and somato-dendritic recordings, anatomical reconstructions, immunohistochemistry, electron microscopy, and modeling. By fitting detailed compartmental models of Golgi cells to their somato-dendritic voltage responses, we determined their passive electrical properties and the mean gap junction conductance (0.9 nS). ..."
Reference:
1 . Szoboszlay M, Lorincz A, Lanore F, Vervaeke K, Silver RA, Nusser Z (2016) Functional Properties of Dendritic Gap Junctions in Cerebellar Golgi Cells. Neuron 90:1043-56 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum golgi cell;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; neuroConstruct;
Model Concept(s):
Implementer(s): Szoboszlay, M [szoboszlay.miklos at koki.mta.hu];
//moddir 01_Soma-dendritic_recordings/01_Control/140311-C1/syncytium/num10
load_file("nrngui.hoc")

// folders with init_fitting.hoc
strdef str1, str2, str3, str4, str5, str6, str7, str8, str9, str10, str11, str12
str1="01_Soma-dendritic_recordings/01_Control/140307-C1/"
str2="01_Soma-dendritic_recordings/01_Control/140311-C0/"
str3="01_Soma-dendritic_recordings/01_Control/140311-C1/single cell/"
str4="01_Soma-dendritic_recordings/01_Control/140311-C1/syncytium/num10/"
str5="01_Soma-dendritic_recordings/01_Control/140311-C1/syncytium/num3/"
str6="01_Soma-dendritic_recordings/01_Control/140403-C0/"
str7="01_Soma-dendritic_recordings/01_Control/140403-C1/"
str8="01_Soma-dendritic_recordings/02_Mefloquine/150430-C1/"
str9="01_Soma-dendritic_recordings/02_Mefloquine/150602-C4/"
str10="01_Soma-dendritic_recordings/02_Mefloquine/150603-C0/"
str11="01_Soma-dendritic_recordings/02_Mefloquine/150603-C3/"
str12="01_Soma-dendritic_recordings/02_Mefloquine/150717-C0/"

strdef str13, str14, str15, str16, str17, str18
// folders with init_auto_fitting.hoc
str13="01_Soma-dendritic_recordings/01_Control/140311-C1/syncytium/num10/"
str14="01_Soma-dendritic_recordings/01_Control/140311-C1/syncytium/num3/"
str15="02_Somatic_paired_recordings/140514-C2/"
str16="02_Somatic_paired_recordings/140610-C0/"
str17="02_Somatic_paired_recordings/140610-C1/"
str18="02_Somatic_paired_recordings/140624-C0/"

xpanel("Szoboszlay et al 2016 simulations")
  xlabel("Select Quit in between simulations")
  xbutton("Quit","quit()")
  xlabel("Choose a simulation by clicking below.")
  xlabel("init_fitting:")
  xlabel("(click \"Error Value\" in window MulRunFitter[0] Generators)")
  xbutton(str1, "load_sim(str1)")
  xbutton(str2, "load_sim(str2)")
  xbutton(str3, "load_sim(str3)")
  xbutton(str4, "load_sim(str4)")
  xbutton(str5, "load_sim(str5)")
  xbutton(str6, "load_sim(str6)")
  xbutton(str7, "load_sim(str7)")
  xbutton(str8, "load_sim(str8)")
  xbutton(str9, "load_sim(str9)")
  xbutton(str10, "load_sim(str10)")
  xbutton(str11, "load_sim(str11)")
  xbutton(str12, "load_sim(str12)")

  xlabel("folders with init_auto_fitting:")
  xbutton(str13, "load_sim_auto(str13)")
  xbutton(str14, "load_sim_auto(str14)")
  xbutton(str15, "load_sim_auto(str15)")
  xbutton(str16, "load_sim_auto(str16)")
  xbutton(str17, "load_sim_auto(str17)")
  xbutton(str18, "load_sim_auto(str18)")
xpanel()

// chdir("01_Soma-dendritic_recordings/01_Control/140311-C1/syncytium/num10")
strdef tmpstr
proc load_sim() {
  tmpstr=$s1
  print "loading: ",tmpstr
  chdir(tmpstr)
  load_file("init_fitting.hoc")
}
proc load_sim_auto() {
  tmpstr=$s1
  print "loading: ",tmpstr
  chdir(tmpstr)
  load_file("init_auto_fitting.hoc")
}