Pallidostriatal projections promote beta oscillations (Corbit, Whalen, et al 2016)

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Accession:227577
This model consists of an inhibitory loop combining the projections from GPe neurons back to the striatum (shown experimentally to predominantly affect fast spiking interneurons, FSIs), together with the coupling from FSIs to medium spiny neurons (MSNs) in the striatum, along with the projections from MSNs to GPe. All models are in the Hodgkin-Huxley formalism, adapted from previously published models for each cell type. The connected circuit produces irregular activity under control conditions, but increasing FSI-to-MSN connectivity as observed experimentally under dopamine depletion yields exaggerated beta oscillations and synchrony. Additional mechanistic aspects are also explored.
Reference:
1 . Corbit VL, Whalen TC, Zitelli KT, Crilly SY, Rubin JE, Gittis AH (2016) Pallidostriatal Projections Promote ß Oscillations in a Dopamine-Depleted Biophysical Network Model. J Neurosci 36:5556-71 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron; Hodgkin-Huxley neuron; Neostriatum fast spiking interneuron; Neostriatum spiny neuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: XPP;
Model Concept(s): Oscillations; Synchronization;
Implementer(s): Rubin, Jonathan E [jonrubin at pitt.edu]; Whalen, Timothy C [timcwhalen at gmail.com]; Corbit, Victoria L [vic22 at pitt.edu];
Search NeuronDB for information about:  GabaA; Glutamate; Gaba; Glutamate;