L4 cortical barrel NN model receiving thalamic input during whisking or touch (Gutnisky et al. 2017)

 Download zip file 
Help downloading and running models
Accession:228596
Excitatory neurons in layer 4 (L4) in the barrel cortex respond relatively strongly to touch but not to whisker movement (Yu et al., Nat. Neurosci. 2016). The model explains the mechanism underlying this effect. The network is settled to filter out most stationary inputs. Brief touch input passes through because it takes time until feed-forward inhibition silences excitatory neurons receiving brief and strong thalamic excitation.
Reference:
1 . Gutnisky DA, Yu J, Hires SA, To MS, Bale M, Svoboda K, Golomb D (2017) Mechanisms underlying a thalamocortical transformation during active tactile sensation PLoS Comput Biol 13(6):e1005576
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Barrel cortex; Mouse;
Cell Type(s): Neocortex layer 4 neuron; Abstract Wang-Buzsaki neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: C or C++ program;
Model Concept(s): Sensory processing; Touch; Whisking;
Implementer(s): Golomb, David [golomb at bgu.ac.il];
Search NeuronDB for information about:  I Na,t; I K; Gaba; Glutamate;
figure6a.com: generates voltage time courses of 8 E neurons and 8 I neurons
without touch. The top two traces are plotted in Fig. 6a.

figure6b.com: generates the firing rate nu vs. A_T for whisking without
touch.

figure6c.com: generates voltage time courses of 8 E neurons and 8 I neurons
with touch. The top two traces are plotted in Fig. 6c.

figure6d_8di.com: generates the histograms of Fig. 6d (identical to 8f,g),
Fig. 8d,e and Fig. 8 h,i.

figure7d.com: generates graphs of R (spikes/touch) vs. tau_delay^EI of Fig. 7a.

figure7d.com: generates graphs of R (spikes/touch) vs. t_AMPA of Fig. 7b.

figure7d.com: generates graphs of R (spikes/touch) vs. C_T of Fig. 7c.

figure7d.com: generates graphs of R (spikes/touch) vs. A_T of Fig. 7d.

figure8c.com: generates graphs of R (spikes/touch) vs. g_EE of Fig. 8c.

figure11ab.com: generates graphs of nu (spikes/s) with halo activation by
photostimulation vs. nu without photostimulaton for the L4E, L4I(Hr^+) and
L4I(Hr-) neurons. Fig. 11a,b.

figure11cdef.com: generates graphs of R (spikes/touch) with halo activation by
photostimulation vs. R without photostimulaton for the L4E, L4I(Hr^+) and
L4I(Hr-) neurons. Fig. 11c,d. In addition, histograms of spikes/s after touch
are generated for the 3 neuronal populations, Fig. 11e,f. The program uses the
file tc.fri.b8 produced by the command procedure figure6d.com .

figure11gh.com: generates the firing rate nu vs. A_T for whisking without
touch for the three neuronal populations: L4E, L4I(Hr+) and L4I(Hr-).

figure12a.com: generates graphs of R (spikes/touch) vs. f_halo of Fig. 12a.

figure12b.com: generates graphs of nu (spikes/s) vs. f_halo of Fig. 12b.