The origin of different spike and wave-like events (Hall et al 2017)

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Accession:235561
Acute In vitro models have revealed a great deal of information about mechanisms underlying many types of epileptiform activity. However, few examples exist that shed light on spike and wave (SpW) patterns of pathological activity. SpW are seen in many epilepsy syndromes, both generalised and focal, and manifest across the entire age spectrum. They are heterogeneous in terms of their severity, symptom burden and apparent anatomical origin (thalamic, neocortical or both), but any relationship between this heterogeneity and underlying pathology remains elusive. Here we demonstrate that physiological delta frequency rhythms act as an effective substrate to permit modelling of SpW of cortical origin and may help to address this issue. ..."
Reference:
1 . Hall SP, Traub RD, Adams NE, Cunningham MO, Schofield I, Jenkins AJ, Whittington MA (2017) Enhanced interlaminar excitation or reduced superficial layer inhibition in neocortex generates different spike and wave-like electrographic events in vitro. J Neurophysiol :jn.00516.2017 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex; Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal neuron; Thalamus reticular nucleus cell; Neocortex U1 pyramidal corticalthalamic L6 cell; Neocortex U1 pyramidal intratelencephalic L2-6 cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: FORTRAN;
Model Concept(s): Epilepsy;
Implementer(s): Traub, Roger D ;
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal neuron; Thalamus reticular nucleus cell; Neocortex U1 pyramidal intratelencephalic L2-6 cell; Neocortex U1 pyramidal corticalthalamic L6 cell; GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow;
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HallEtAl2017
readme.txt
dexptablebig_setup.f *
dexptablesmall_setup.f *
fnmda.f *
groucho_gapbld.f *
groucho_gapbld_mix.f *
groucho_gapbld_mix.f'A=0
integrate_deepaxaxx.f *
integrate_deepbaskx.f *
integrate_deepLTSx.f *
integrate_deepng.f *
integrate_nontuftRSXXB.f *
integrate_nrtxB.f *
integrate_spinstelldiegoxB.f *
integrate_supaxaxx.f *
integrate_supbaskx.f *
integrate_supLTSX.f *
integrate_supng.f *
integrate_supng.f'A=0
integrate_suppyrFRBxPB.f *
integrate_suppyrRS.f *
integrate_suppyrRSXPB.f *
integrate_tcrxB.f *
integrate_tuftIBVx3B.f *
integrate_tuftRSXXB.f *
makefile *
otis_table_setup.f *
spikewaveS96.f
spikewaveS96.pdf
synaptic_map_construct.f *
                            
This is the readme for the fortran programs associated with the paper:

Hall SP, Traub RD, Adams NE, Cunningham MO, Schofield I, Jenkins AJ,
Whittington MA (2017) Enhanced interlaminar excitation or reduced
superficial layer inhibition in neocortex generates different spike
and wave-like electrographic events in vitro. J Neurophysiol
:jn.00516.2017

These files were contributed by Roger Traub.

The fortran can be compiled with the makefile however requires an
object file gettime.o which is available elsewhere.