"A resurgence has taken place in recent years in the use of the
extracellularly recorded local field potential (LFP) to investigate
neural network activity. To probe monosynaptic thalamic activation of
cortical postsynaptic target cells, so called spike-trigger-averaged
LFP (stLFP) signatures have been measured. In these experiments, the
cortical LFP is measured by multielectrodes covering several cortical
lamina and averaged on spontaneous spikes of thalamocortical (TC)
cells. Using a well established forward-modeling scheme, we
investigated the biophysical origin of this stLFP signature with
simultaneous synaptic activation of cortical layer-4 neurons,
mimicking the effect of a single afferent spike from a single TC
neuron.
..."
Reference:
1 .
Hagen E, Fossum JC, Pettersen KH, Alonso JM, Swadlow HA, Einevoll GT (2017) Focal Local Field Potential Signature of the Single-Axon Monosynaptic Thalamocortical Connection. J Neurosci 37:5123-5143 [PubMed]
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